scholarly journals CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES FROM SILKWORM EGGS: OCCURRENCE OF TWO CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, CHANGES IN THEIR ACTIVITIES AND LEVELS OF CYCLIC NUCLEOTIDES DURING DEVELOPMENT OF THE EGGS

1975 ◽  
Vol 17 (3) ◽  
pp. 227-235 ◽  
Author(s):  
SUSUMU Y. TAKAHASHI ◽  
TADAKAZU OHOKA ◽  
KAZUNORI HANAOKA ◽  
TAKASHI KAGEYAMA ◽  
EIJI OHNISHI
Keyword(s):  
Protein Kinases ◽  
Cyclic Nucleotides ◽  
Cyclic Nucleotide ◽  
Dependent Protein

scholarly journals Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells.

1980 ◽  
Vol 87 (2) ◽  
pp. 336-345 ◽  
Author(s):  
C L Browne ◽  
A H Lockwood ◽  
J L Su ◽  
J A Beavo ◽  
A L Steiner
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Protein Kinases ◽  
Cyclic Gmp ◽  
Cyclic Nucleotides ◽  
Mitotic Spindle ◽  
Cyclic Nucleotide ◽  
Dependent Protein Kinase ◽  
Mitotic Apparatus ◽  
Dependent Protein

Cyclic nucleotides and cyclic nucleotide-dependent protein kinases have been implicated in the regulation of cell motility and division, processes that depend on the cell cytoskeleton. To determine whether cyclic nucleotides or their kinases are physically associated with the cytoskeleton during cell division, fluorescently labeled antibodies directed against cyclic AMP, cyclic GMP, and the cyclic nucleotide-dpendent protein kinases were used to localize these molecules in mitotic PtK1 cells. Both the cyclic GMP-dependent protein kinase and the type II regulatory subunit of the cyclic AMP-dependent protein kinase were localized on the mitotic spindle. Throughout mitosis, their distribution closely resembled that of tubulin. Antibodies to cyclic AMP, cyclic GMP, and the type I regulatory and catalytic subunits of the cyclic AMP-dependent protein kinase did not label the mitotic apparatus. The association between specific components of the cyclic neucleotide system and the mitotic spindle suggests that cyclic nucleotide-dependent phosphorylation of spindle proteins, such as those of microtubules, may play a fundamental role in the regulation of spindle assembly and chromosome motion.

scholarly journals Cyclic nucleotide-dependent protein kinases in airway smooth muscle.

1982 ◽  
Vol 257 (19) ◽  
pp. 11609-11616 ◽  
Author(s):  
T J Torphy ◽  
W B Freese ◽  
G A Rinard ◽  
L L Brunton ◽  
S E Mayer
Keyword(s):  
Smooth Muscle ◽  
Protein Kinases ◽  
Airway Smooth Muscle ◽  
Cyclic Nucleotide ◽  
Dependent Protein

scholarly journals Cyclic Nucleotide-dependent Protein Kinases

1969 ◽  
Vol 244 (23) ◽  
pp. 6395-6402 ◽  
Author(s):  
Eishichi Miyamoto ◽  
J.F. Kuo ◽  
Paul Greengard
Keyword(s):  
Protein Kinases ◽  
Cyclic Nucleotide ◽  
Dependent Protein
Sign in / Sign up

Export Citation Format

Share Document