VITAMIN K PROPHYLAXIS FOR HAEMORRHAGIC DISEASE IN INFANCY.

AbstractWe looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources. We summarized the recommendations and the strength of the recommendation when and as reported by the authors. We summarized the main findings of systematic reviews with the certainty of the evidence as reported.All newborns should receive vitamin K prophylaxis, as it has been proven that oral and intramuscular prophylactic vitamin K given after birth are effective for preventing classical HDN. There are no randomized trials looking at the efficacy of vitamin K supplement on late HDN. There are no randomized trials comparing the oral and intramuscular route of administration of prophylactic vitamin K in newborns. From older trials and surveillance data, it seems that there is no significant difference between the intramuscular and the oral regimens for preventing classical and late HDN, provided that the oral regimen is duly completed. Evidence assessing vitamin K prophylaxis in preterm infants is scarce.

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Oral vitamin K prophylaxis and late haemorrhagic disease of the newborn

The Lancet ◽

10.1016/s0140-6736(94)91187-8 ◽

1994 ◽

Vol 343 (8893) ◽

pp. 352 ◽

Cited By ~ 15

Author(s):

Rüdiger von Kries ◽

Ulrich Göbel

Keyword(s):

Vitamin K ◽

Oral Vitamin ◽

Vitamin K Prophylaxis ◽

Haemorrhagic Disease

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Vitamin K prophylaxis against haemorrhagic disease of the newborn in the United Kingdom.

BMJ ◽

10.1136/bmj.303.6810.1109 ◽

1991 ◽

Vol 303 (6810) ◽

pp. 1109-1109 ◽

Cited By ~ 17

Author(s):

J Handel ◽

J H Tripp

Keyword(s):

United Kingdom ◽

Vitamin K ◽

Vitamin K Prophylaxis ◽

The United Kingdom ◽

Haemorrhagic Disease

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VITAMIN K PROPHYLAXIS IN INFANTS

10.2196/preprints.10416 ◽

2018 ◽

Author(s):

Zuzana Lihanova

Keyword(s):

Vitamin K ◽

Vitamin K Prophylaxis

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Haemorrhagic disease and vitamin K.

Archives of Disease in Childhood ◽

10.1136/adc.62.9.979 ◽

1987 ◽

Vol 62 (9) ◽

pp. 979-979

Author(s):

B L Priestley

Keyword(s):

Vitamin K ◽

Haemorrhagic Disease

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Hemorrhage in the newborn and vitamin K prophylaxis

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(65)90223-1 ◽

1965 ◽

Vol 91 (2) ◽

pp. 300

Author(s):

Schuyler G. Kohl

Keyword(s):

Vitamin K ◽

Vitamin K Prophylaxis

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Intracranial Hemorrhage Caused by Vitamin K Deficiency Beyond Neonatal Period

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v37i1.16301 ◽

2017 ◽

Vol 37 (1) ◽

pp. 104-107 ◽

Cited By ~ 1

Author(s):

Sudhir Adhikari ◽

Eva Gauchan ◽

Tejesh Malla ◽

Brijesh Sathian ◽

Kalipatanam Seshagiri Rao

Keyword(s):

Intracranial Hemorrhage ◽

Vitamin K ◽

Neonatal Period ◽

National Policy ◽

Vitamin K Deficiency ◽

Vitamin K Deficiency Bleeding ◽

Vitamin K Prophylaxis ◽

Clinical Presentations ◽

Intracranial Bleed ◽

K Deficiency

Vitamin K deficiency bleeding (VKDB) can manifest as intracranial hemorrhage (ICH) and is still prevalent in poor resource countries. Infants aged one to twelve months with the diagnosis of ICH from 1st July 2011 to 30th June 2016 were included. There were 16 cases of ICH attributed to vitamin K deficiency. Clinical presentations were anemia16 (100%), bulged fontanel 13(81.3%), seizures 10(62.5%), vomiting 8(50%) and fever 9(56.3%). Mean INR at admission was 8.575±7.267 and 1.868±0.838 after three doses of vitamin K administration. Sites of intracranial bleed were parenchymal 5(31.3%), subdural 4(25%), extradural 2(12.5%), ventricular 2(12.5%). In 3(18.8%) of cases bleeding was more extensive involving more than one site. Mortality was 4(25%) and 3(18.8%) had abnormal neurological findings at discharge. There is an urgent need for national policy for vitamin K prophylaxis at birth.

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