Participation of endothelial cells in the development of glomerulosclerosis: A study on murine serum sickness nephritis with mitomycin C

1996 ◽  
Vol 46 (3) ◽  
pp. 173-182 ◽  
Author(s):  
A. K. M. Rownak Hossain Chowdhury
Keyword(s):  
Endothelial Cells ◽  
Mitomycin C ◽  
Serum Sickness ◽  
Serum Sickness Nephritis

scholarly journals ELECTRON MICROSCOPY OF SERUM SICKNESS NEPHRITIS

1958 ◽  
Vol 108 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Joseph D. Feldman
Keyword(s):  
Electron Microscopy ◽  
Endothelial Cells ◽  
Basement Membrane ◽  
Serum Sickness ◽  
Primary Reaction ◽  
Electron Dense Material ◽  
Renal Lesions ◽  
Microscopic Studies ◽  
Antigen Antibody ◽  
Serum Sickness Nephritis

The renal lesions of serum sickness were studied with the electron microscope. The most prominent change was a marked swelling and proliferation of glomernlar endothelial cells causing obliteration of the capillary lumen. The basement membrane also showed focal thickenings and excrescences. Deposits of electron-dense material blended into the basement membrane. On the extracapillary side epithelial foot processes were reduced in number and replaced by broad sheets of cytoplasm which were closely applied to the basement membrane. From a comparison of electron and fluorescent microscopic studies of the glomerulus in serum sickness, it would seem that antigen-antibody complexes initiated injury in endothelial cells, although the possibility of the primary reaction occurring on basement membrane cannot be excluded.

Anti-nephritic effects of prostaglandin E1 on serum sickness nephritis in rat

Ensho ◽  
1982 ◽  
Vol 2 (4) ◽  
pp. 317-318
Author(s):  
Tadashi Nagamatsu ◽  
Yoshio Suzuki ◽  
Kouji Ikuta ◽  
Shigehisa Aoki
Keyword(s):  
Prostaglandin E1 ◽  
Serum Sickness ◽  
Serum Sickness Nephritis
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