Tumor-infiltrating lymphocytes derived from human renal cell carcinoma: Clonal analysis of its characteristics

2008 ◽  
Vol 15 (3) ◽  
pp. 241-244 ◽  
Author(s):  
Tomoyuki Shimabukuro ◽  
Katsusuke Naito
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Clonal Analysis ◽  
Human Renal Cell Carcinoma ◽  
Infiltrating Lymphocytes

Regulatory effects of interleukin-4 on tumor-infiltrating lymphocytes derived from human renal cell carcinoma

1992 ◽  
Vol 53 (6) ◽  
pp. 602-609 ◽  
Author(s):  
Christian Peyret ◽  
Bernard H. Bochner ◽  
Tchun Y. Lee ◽  
Alec S. Koo ◽  
Jean B. deKernion ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Interleukin 4 ◽  
Human Renal Cell Carcinoma ◽  
Regulatory Effects ◽  
Infiltrating Lymphocytes

Immunohistochemistry of Complement Response on Human Renal Cell Carcinoma Biopsies

1996 ◽  
Vol 82 (5) ◽  
pp. 473-479 ◽  
Author(s):  
Tamás Magyarlaki ◽  
Szilvia Mosolits ◽  
Ferenc Baranyay ◽  
István Buzogány
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Complement Activation ◽  
Renal Cell ◽  
Membrane Attack Complex ◽  
Tumor Infiltrating Lymphocytes ◽  
Complement Pathway ◽  
Histocompatibility Complex ◽  
Pathway Activation ◽  
Infiltrating Lymphocytes

The goal of the study was to characterize the complement humoral and cellular antitumor responses on primary renal cell carcinoma biopsies. As an original observation, complement activation was found on 11/22 cases. Classical complement pathway activation was characterized by tumor C1q complement protein and IgG deposition (5/22 cases). Alternative or nonimmune complement pathway activation was seen as tissue deposition of C3 (6/22 cases). The membrane attack complex was present in cases with alternative complement pathway activation at the sites of tumor necrosis. Renal cell carcinomas with complement activation overexpressed at least one of the complement regulatory factors (membrane cofactor protein, decay accelerating factor, membrane attack complex inhibitor) and major histocompatibility complex class II molecules. Tumor infiltrating lymphocytes were present in most of the renal cell carcinomas with complement activation (8/11). However, the number of tumor-infiltrating lymphocytes was correlated with the intensity of major histocompatibility complex-ll expression in 18/22 cases. Detection of complement activation and immune cell infiltrates on renal cell carcinoma primary biopsies may serve as a new predictive factor for immunotherapy.

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