Adult Onset Still's Disease: A Cause of Pyrexia of Unknown Origin

1982 ◽  
Vol 12 (5) ◽  
pp. 522-524 ◽  
Author(s):  
S. Hall ◽  
I. Epstein ◽  
G. O. Littlejohn
Keyword(s):  
Unknown Origin ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Pyrexia Of Unknown Origin ◽  
Still's Disease ◽  
Adult Onset Still's Disease

ADULT ONSET STILL’S DISEASE PRESENTING AS PYREXIA OF UNKNOWN ORIGIN

2021 ◽  
pp. 43-44
Author(s):  
Naim M Kadri ◽  
Yash S Patel ◽  
Pratvi V Vaishnav ◽  
Smit R Patel
Keyword(s):  
Young Male ◽  
Unknown Origin ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Pyrexia Of Unknown Origin ◽  
Still's Disease ◽  
Sustained Effect ◽  
Yamaguchi Criteria ◽  
Adult Onset Still's Disease

Adult onset Still’s disease (AOSD) is a rare inammatory disease characterized by fever, arthralgia, rash, sore throat, lymphadenopathy, hepatomegaly and/or splenomegaly. It is a rare cause of pyrexia of unknown origin (PUO) and should be considered once the more common infectious, rheumatological and malignant causes have been excluded. This is usually a diagnosis of exclusion. Yamaguchi criteria can be used for diagnosis. Patients of AOSD show an excellent response to Non-steroidal anti-inammatory drugs (NSAIDs), however some may not have a sustained effect, in which case glucocorticoids have to be considered. Here’s a case of a young male patient who was evaluated for the cause of pyrexia of unknown origin.

Aetiology of pyrexia of unknown origin in north India

2020 ◽  
pp. 004947552094790
Author(s):  
Ashok Kumar Pannu ◽  
Rithvik Golla ◽  
Savita Kumari ◽  
Vikas Suri ◽  
Pankaj Gupta ◽  
...  
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Age Groups ◽  
Unknown Origin ◽  
North India ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Pyrexia Of Unknown Origin ◽  
Still's Disease ◽  
Adult Onset Still's Disease

The aetiology of pyrexia of unknown origin (PUO) varies dramatically according to epidemiology. We studied the cause and spectrum of PUO in Indian adults. A total of 152 patients (112 prospectively and 40 retrospectively) met Petersdorf and Beeson's criteria. The diagnostic evaluation was guided by potentially diagnostic clues, based on a ‘step-wise’ approach. The five main categories, i.e. infectious, neoplastic, non-infectious inflammatory, miscellaneous and undiagnosed comprised 43.4%, 21.5%, 19.7%, 2.0% and 12.5%, respectively. The top three causes were tuberculosis (n = 43, 28.3%), lymphoma (n = 19, 12.5%) and adult-onset Still's disease (n = 12, 7.9%). Tuberculosis predominated in all age groups, and about 70% of cases had the extrapulmonary form, the most common being gastrointestinal. Hodgkin and non-Hodgkin lymphomas were equally distributed, but solid malignancies were uncommon. Adult-onset Still's disease was the second commonest cause in adults aged ≤ 40 years. Fever resolved spontaneously in 12/19 cases of undiagnosed cause. Extrapulmonary tuberculosis remains the most prevalent PUO in India.

scholarly journals Adult-onset Still’s disease, the most internistic of the rheumatic diseases: current concepts and a report of six cases

2013 ◽  
pp. 259-264
Author(s):  
Roberto Boni ◽  
Pier G. Rabitti
Keyword(s):  
Serum Ferritin ◽  
Hemophagocytic Syndrome ◽  
Unknown Origin ◽  
Essential Elements ◽  
Adult Onset Still’S Disease ◽  
Inflammatory Disorder ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Adult Onset Still's Disease

Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown origin. It is characterized by spiking fever, evanescent rash, arthralgia/arthritis, and leukocytosis. The differential diagnosis includes a number of other conditions, and management is complicated by the lack of course predictors and the risks associated with complications and treatments. This report examines recent advances in our understanding of adult-onset Still’s disease (pathogenesis, diagnosis, complications, treatment). Current research in this field is focused on the significance of serum ferritin in AOSD, mechanisms underlying the hemophagocytic syndrome, and use of biologic therapies in patients who are refractory to conventional treatment. Six cases of AOSD diagnosed by our staff between 2002 and 2009 are also analyzed and compared with other cases reported in the literature. This analysis showed that Still’s rash and serum ferritin levels were not essential elements for diagnosis. In addition, the course of the disease showed little relation to the severity / characteristics of the presenting picture, but the evolution worsened with the age of the patient at diagnosis.

scholarly journals Effect of Ultrasound Therapy on the Adult-Onset Still’s Disease: A Case Study

2020 ◽  
Vol 10 (1) ◽  
pp. 49-54
Author(s):  
Manal Yooussef ◽  
Keyword(s):  
Short Form ◽  
Unknown Origin ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Timed Up And Go ◽  
Still's Disease ◽  
Muscle Testing ◽  
Systemic Inflammatory Disease ◽  
Adult Onset Still's Disease

Adult Onset Still’s Disease (AOSD) is a rare systemic inflammatory disease of unrecognized etiology and pathogenesis that presents in 5% to 10% of patients as Fever of Unknown Origin (FUO) accompanied by systemic manifestations. We reported a compelling case of a 39-year-old African male who presented with a one-month duration FUO along with skin rash, sore throat, and arthralgia. After an extensive workup, potential differential diagnoses were ruled out, and the patient was diagnosed with AOSD based on the Yamaguchi criteria. After the application of Ultrasound (US) and exercises on both ankles as well as left knee, left elbow, and left wrist, there was an improvement of Visual Analogue Scale by 66.6%, Five Repetition Sit to Stand Test (FRSTS) improved 50%, Timed Up and Go (TUG) test improved 87.5%, and there was also an improvement in the 36-Item Short Form Survey (SF-36), and muscle testing. This result was due to the anti-inflammatory effect of the US, leading to decrease pain and improve function in the individuals.

scholarly journals Adult onset Still’s disease presenting as fever of unknown origin: a case report with review of literature

2017 ◽  
Vol 11 ◽  
Author(s):  
Harpreet Singh ◽  
Deepak Jain ◽  
Saroj Dhankhar ◽  
Rekha Mathur
Keyword(s):  
Joint Pain ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Rheumatologic Diseases ◽  
Systemic Inflammatory Disease ◽  
Adult Onset Still's Disease

Adult onset Still’s disease (AOSD) is a systemic inflammatory disease with exact etiology and pathogenesis yet to be discovered. AOSD, being an important cause of fever of unknown origin, is diagnosed after ruling out infections, malignancy and other rheumatologic diseases. It may present with fever without typical rash although typical triad is of fever, joint pain and rash. A 35-year old previously healthy man was referred to our hospital with 6 months of fever, joint pain and weight loss. Examination and investigations revealed anaemia, leukocytosis (predominant neutrophilia), lymphadenopathy, hepatomegaly, arthritis and evidence of interstitial lung disease with raised serum ferritin levels. The hematological disorders, infections and other rheumatologic diseases were excluded. The diagnosis of adult onset Still’s disease can be very difficult as there are no specific tests and diagnosis is based on symptom complex. AOSD presenting as fever of unknown origin could be a challenge for the physician to diagnose and manage timely.

scholarly journals ADULT ONSET STILL'S DISEASE AS FEVER OF UNKNOWN ORIGIN - A CASE REPORT

2021 ◽  
Author(s):  
Jéssica Tomps Corrêa ◽  
Gabriela Ferreira Rocha ◽  
Vinícius Shinoda Pereira ◽  
Victor Gomes Rocha ◽  
Erickson Gomes Gutierrez ◽  
...  
Keyword(s):  
Case Report ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Adult Onset Still's Disease
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