scholarly journals Is the Capacity for Optic Nerve Regeneration Related to Continued Retinal Ganglion Cell Production in the Frog?. A Test of the Hypothesis that Neurogenesis and Axon Regeneration are Obligatorily Linked

1989 ◽  
Vol 1 (6) ◽  
pp. 626-638 ◽  
Author(s):  
J. S. H. Taylor ◽  
J. L. Jack ◽  
S. S. Easter
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Regeneration ◽  
Retinal Ganglion Cell ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Cell Production ◽  
Optic Nerve Regeneration

scholarly journals Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis

2017 ◽  
Vol 426 (2) ◽  
pp. 360-373 ◽  
Author(s):  
G.B. Whitworth ◽  
B.C. Misaghi ◽  
D.M. Rosenthal ◽  
E.A. Mills ◽  
D.J. Heinen ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Xenopus Laevis ◽  
Ganglion Cell ◽  
Nerve Regeneration ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Optic Nerve Regeneration

scholarly journals Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Tian Wang ◽  
Yiming Li ◽  
Miao Guo ◽  
Xue Dong ◽  
Mengyu Liao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Neuropathy ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Traumatic Optic Neuropathy ◽  
Fiber Layer

Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading to partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged as a promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes as nanosized vesicles for the delivery of PACAP38 loaded via the exosomal anchor peptide CP05 (EXOPACAP38). EXOPACAP38 showed greater uptake efficiency in vitro and in vivo than PACAP38. The results showed that EXOPACAP38 significantly enhanced the RGC survival rate and retinal nerve fiber layer thickness in a rat TON model. Moreover, EXOPACAP38 significantly promoted axon regeneration and optic nerve function after injury. These findings indicate that EXOPACAP38 can be used as a treatment option and may have therapeutic implications for patients with TON.

Retinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve

2021 ◽  
pp. JN-RM-0555-21
Author(s):  
Sheri L. Peterson ◽  
Yiqing Li ◽  
Christina J. Sun ◽  
Kimberly A. Wong ◽  
Kylie S. Leung ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Axon Regeneration ◽  
Cell Activity ◽  
Myeloid Cell ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon
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