Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice

2005 ◽  
Vol 21 (5) ◽  
pp. 1379-1384 ◽  
Author(s):  
P. D. Skoubis ◽  
H. A. Lam ◽  
J. Shoblock ◽  
S. Narayanan ◽  
N. T. Maidment
Keyword(s):  
Endogenous Enkephalins

CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins

1997 ◽  
Vol 132 (3) ◽  
pp. 227-236 ◽  
Author(s):  
Claire Smadja ◽  
Fernando Ruiz ◽  
Pascale Coric ◽  
Marie Claude Fournié-Zaluski ◽  
Bernard P. Roques ◽  
...  
Keyword(s):  
Limbic System ◽  
Endogenous Enkephalins

Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins

1996 ◽  
Vol 215 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Michael L. Nichols ◽  
Di Bian ◽  
Michael H. Ossipov ◽  
T.Philip Malan ◽  
Frank Porreca
Keyword(s):  
Endogenous Enkephalins

Evidence that endogenous enkephalins produce δ-opiate receptor mediated neuronal inhibitions in rat dorsal horn

1986 ◽  
Vol 72 (2) ◽  
pp. 179-182 ◽  
Author(s):  
A.H. Dickenson ◽  
A. Sullivan ◽  
C. Feeney ◽  
M.C. Fournie-Zaluski ◽  
B.P. Roques
Keyword(s):  
Dorsal Horn ◽  
Opiate Receptor ◽  
Endogenous Enkephalins

Selective participation of both “enkephalinase” and aminopeptidase activities in the metabolism of endogenous enkephalins

Life Sciences ◽  
1982 ◽  
Vol 31 (16-17) ◽  
pp. 1753-1756 ◽  
Author(s):  
Sophie de la Baume ◽  
Claude Gros ◽  
Ching Cheng Yi ◽  
Pierre Chaillet ◽  
Hélène Marcais-Collado ◽  
...  
Keyword(s):  
Endogenous Enkephalins

scholarly journals Analgesia linked to Nav1.7 loss of function requires μ and δ opioid receptors

2018 ◽  
Author(s):  
Vanessa Pereira ◽  
Queensta Millet ◽  
Jose Aramburu ◽  
Cristina Lopez-Rodriguez ◽  
Claire Gaveriaux Ruff ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Neurotransmitter Release ◽  
Null Mouse ◽  
Channel Blockers ◽  
Loss Of Function ◽  
Analgesic Drug ◽  
Gene Encoding ◽  
Binding Motifs ◽  
Opioid Receptor Antagonists ◽  
Endogenous Enkephalins

AbstractFunctional deletion of the SCN9A gene encoding sodium channel Nav1.7 makes humans and mice pain-free (1,2). Opioid signaling contributes to this analgesic state (3). Here we show that the pharmacological block or deletion of both μ and δ opioid receptors is required to abolish Nav1.7 null opioid-related analgesia.κ-opioid receptor antagonists were without effect. Enkephalins encoded by the Penk gene are upregulated in Nav1.7 nulls (3). Deleting Nfat5, a transcription factor with binding motifs upstream of Penk (4), induces the same level of enkephalin mRNA expression as found in Nav1.7 nulls, but without consequent analgesia. These data confirm that a combination of events linked to SCN9A gene loss is required for analgesia. Higher levels of endogenous enkephalins (3), potentiated opioid receptors (5), diminished electrical excitability (6,7) and loss of neurotransmitter release (2,1) together contribute to the analgesic phenotype found in Nav1.7 null mouse and human mutants. These observations help explain the failure of Nav1.7 channel blockers alone to produce analgesia and suggest new routes for analgesic drug development.

Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model

1998 ◽  
Vol 354 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Purificación Tejedor-Real ◽  
Juan A. Micó ◽  
Claire Smadja ◽  
Rafael Maldonado ◽  
Bernard P. Roques ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Learned Helplessness ◽  
Endogenous Enkephalins ◽  
Helplessness Model
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