Effects of Hypoxia on the Activity of the Dopaminergic Neuron System in the Rat Striatum as Studied by In Vivo Brain Microdialysis

1991 ◽  
Vol 57 (3) ◽  
pp. 997-1002 ◽  
Author(s):  
Yoshinori Akiyama ◽  
Kunio Koshimura ◽  
Tetsuya Ohue ◽  
Ken Lee ◽  
Soichi Miwa ◽  
...  
Keyword(s):  
Dopaminergic Neuron ◽  
Rat Striatum ◽  
Brain Microdialysis ◽  
Neuron System

Modification of the striatal dopaminergic neuron system by carbon monoxide exposure in free-moving rats, as determined by in vivo brain microdialysis

2002 ◽  
Vol 76 (10) ◽  
pp. 596-605 ◽  
Author(s):  
Shuichi Hara ◽  
Toshiji Mukai ◽  
Kunihiko Kurosaki ◽  
Fumi Kuriiwa ◽  
Takahiko Endo
Keyword(s):  
Carbon Monoxide ◽  
Dopaminergic Neuron ◽  
Brain Microdialysis ◽  
Neuron System

Effects of CGP 28014 on the in vivo release and metabolism of dopamine in the rat striatum assessed by brain microdialysis

1993 ◽  
Vol 18 (11) ◽  
pp. 1131-1136 ◽  
Author(s):  
Anne-Fran�oise Steulet ◽  
Kurt St�cklin ◽  
Peter Wicki ◽  
Peter Waldmeier
Keyword(s):  
Rat Striatum ◽  
Brain Microdialysis ◽  
In Vivo Release

scholarly journals Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques

2020 ◽  
Vol 22 (5) ◽  
pp. 1244-1254
Author(s):  
M. Mousavinejad ◽  
S. Skidmore ◽  
F. G. Barone ◽  
P. Tyers ◽  
V. Pisupati ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mr Imaging ◽  
Dopaminergic Neuron ◽  
Imaging Techniques ◽  
Embryonic Stem ◽  
Rat Striatum ◽  
Non Invasive ◽  
Bimodal Imaging ◽  
Animal Growth

Abstract Purpose Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells (DAPCs) are a potential therapy for Parkinson’s disease (PD). However, their intracranial administration raises safety concerns including uncontrolled proliferation, migration and inflammation. Here, we apply a bimodal imaging approach to investigate the fate of DAPC transplants in the rat striatum. Procedures DAPCs co-expressing luciferase and ZsGreen or labelled with micron-sized particles of iron oxide (MPIOs) were transplanted in the striatum of RNU rats (n = 6 per group). DAPCs were tracked in vivo using bioluminescence and magnetic resonance (MR) imaging modalities. Results Transgene silencing in differentiating DAPCs accompanied with signal attenuation due to animal growth rendered the bioluminescence undetectable by week 2 post intrastriatal transplantation. However, MR imaging of MPIO-labelled DAPCs showed that transplanted cells remained at the site of injection for over 120 days. Post-mortem histological analysis of DAPC transplants demonstrated that labelling with either luciferase/ZsGreen or MPIOs did not affect the ability of cells to differentiate into mature dopaminergic neurons. Importantly, labelled cells did not elicit increased glial reactivity compared to non-labelled cells. Conclusions In summary, our findings support the transplantation of hPSC-derived DAPCs as a safe treatment for PD.

Effects of Manganese on Extracellular Levels of Dopamine in Rat Striatum: An Analysis In vivo by Brain Microdialysis

2005 ◽  
Vol 30 (9) ◽  
pp. 1147-1154 ◽  
Author(s):  
L. Vidal ◽  
M. Alfonso ◽  
F. Campos ◽  
L. R. F. Faro ◽  
R. C. Cervantes ◽  
...  
Keyword(s):  
Rat Striatum ◽  
Brain Microdialysis

Effects of Choline Administration on In Vivo Release and Biosynthesis of Acetylcholine in the Rat Striatum as Studied by In Vivo Brain Microdialysis

1990 ◽  
Vol 54 (2) ◽  
pp. 533-539 ◽  
Author(s):  
Kunio Koshimura ◽  
Soichi Miwa ◽  
Ken Lee ◽  
Yasunori Hayashi ◽  
Hiroshi Hasegawa ◽  
...  
Keyword(s):  
Rat Striatum ◽  
Brain Microdialysis ◽  
In Vivo Release
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