1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH

2004 ◽  
Vol 91 (2) ◽  
pp. 263-273 ◽  
Author(s):  
Ravi Shankar Akundi ◽  
Antonio Macho ◽  
Eduardo Munoz ◽  
Klaus Lieb ◽  
Gerhard Bringmann ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Induced Apoptosis

scholarly journals Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation

2001 ◽  
Vol 268 (5) ◽  
pp. 1352-1362 ◽  
Author(s):  
Alain Lombet ◽  
Violetta Zujovic ◽  
Mustapha Kandouz ◽  
Claude Billardon ◽  
Santos Carvajal-Gonzalez ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Differentiation ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Induced Apoptosis

Protective Effect of Acanthopanax senticosus Against Ethanol-Induced Apoptosis of Human Neuroblastoma Cell Line SK-N-MC

2003 ◽  
Vol 31 (03) ◽  
pp. 379-388 ◽  
Author(s):  
Mi-Hyeon Jang ◽  
Min-Chul Shin ◽  
Youn-Jung Kim ◽  
Chang-Ju Kim ◽  
Joo-Ho Chung ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cell Line ◽  
Caspase 3 ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Human Neuroblastoma Cell ◽  
Acanthopanax Senticosus ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line ◽  
Induced Apoptosis

The protective effect of Acanthopanax senticosus (AS) against ethanol (EtOH)-induced apoptosis of the human neuroblastoma cell line SK-N-MC was investigated via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), and caspase-3 assay. It was shown that cells treated with EtOH exhibit classical apoptotic features, while cells pre-treated with Acanthopanax senticosus prior to EtOH exposure showed decreased occurrence of apoptotic features. In addition, Acanthopanax senticosus pre-treatment was shown to inhibit EtOH-induced increase in caspase-3 mRNA expression and activity. These results suggest that Acanthopanax senticosus may exert a protective effect against EtOH-induced apoptosis of human neuroblastoma cells.

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