scholarly journals Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery

1994 ◽  
Vol 111 (1) ◽  
pp. 165-172 ◽  
Author(s):  
Takeo Itoh ◽  
Shinichi Ito ◽  
Jonaid Shafiq ◽  
Hikaru Suzuki
Keyword(s):  
Smooth Muscle ◽  
Mesenteric Artery ◽  
K Channel ◽  
Channel Opener ◽  
Rabbit Mesenteric Artery ◽  
K Channel Opener

Effects of BRL 34915, a putative K channel opener, on transmembrane 45Ca movements in rabbit aortic smooth muscle

1988 ◽  
Vol 155 (3) ◽  
pp. 229-237 ◽  
Author(s):  
Peter J.S. Chiu ◽  
Glen Tetzloff ◽  
Ho-Sam Ahn ◽  
Edmund J. Sybertz
Keyword(s):  
Smooth Muscle ◽  
K Channel ◽  
Aortic Smooth Muscle ◽  
Channel Opener ◽  
K Channel Opener

Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery

1995 ◽  
Vol 269 (5) ◽  
pp. C1112-C1118 ◽  
Author(s):  
J. M. Quayle ◽  
A. D. Bonev ◽  
J. E. Brayden ◽  
M. T. Nelson
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Mesenteric Artery ◽  
Katp Channels ◽  
Muscle Cells ◽  
K Channel ◽  
Patch Clamp Technique ◽  
Functional Studies ◽  
Rabbit Mesenteric Artery ◽  
K Currents

The inference that ATP-sensitive K+ (KATP) channels are involved in arterial responses to the synthetic K+ channel openers, hypoxia, adenosine, and calcitonin gene-related peptide, has relied on the sensitivity of these responses to the sulfonylureas glibenclamide and tolbutamide and to tetraethylammonium (TEA+). The inhibition of KATP currents by glibenclamide, tolbutamide, and TEA+ was investigated in single smooth muscle cells from rabbit mesenteric artery by use of the whole cell patch-clamp technique. The synthetic K+ channel openers pinacidil (half-activation 0.6 microM), cromakalim (half-activation 1.9 microM), and diazoxide (half-activation 37.1 microM) activated K(+)-selective currents that were blocked by glibenclamide. Elevation of pipette (intracellular) ATP concentration decreased K+ currents induced by pinacidil. Half-inhibition of KATP currents by glibenclamide and tolbutamide occurred at 101 nM and 351 microM, respectively. KATP currents were also inhibited by external TEA+, with half-inhibition at 6.2 mM. The results indicate that glibenclamide is an effective inhibitor of KATP channels in arterial smooth muscle and that tolbutamide and TEA+ are much less effective. Furthermore, these results support numerous functional studies that have demonstrated that the vasorelaxations to K+ channel openers are inhibited by < 10 microM glibenclamide but not by < 1 mM TEA+.

Electrophysiological actions of a novel K+ channel opener MCC-134 on rabbit portal vein smooth muscle

1999 ◽  
Vol 384 (2-3) ◽  
pp. 203-212 ◽  
Author(s):  
Hiromitsu Morita ◽  
Kazunori Yamada ◽  
Kihachiro Abe ◽  
Yushi Ito ◽  
Ryuji Inoue
Keyword(s):  
Smooth Muscle ◽  
Portal Vein ◽  
K Channel ◽  
Channel Opener ◽  
Rabbit Portal Vein ◽  
K Channel Opener
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