Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats

In chloralose anesthetized and paralyzed spontaneously hypertensive rats (SHR) a somatosympathetic reflex in the cervical sympathetic trunk elicited by a single electrical shock to forelimb afferent fibres in the median nerve was recorded. It has been shown that the somatosympathetic reflex consists of two responses and following silent period. The А-response evoked by the somatic myelinated afferent fibres stimulation, and C-respon.se elicited by the both stimulation of myelinated and unmyelinated afferent fibres. The silent period occurred with the myelinated fibres stimulation. Its duration was proportional to the electrical shock amplitude. The А-response consisted of four waves, the three of them formed early and late responses.

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Effects of Gegen (Puerariae lobatae Radix) water extract on improving detrusor overactivity in spontaneously hypertensive rats

Phytomedicine ◽

10.1016/j.phymed.2016.03.002 ◽

2016 ◽

Vol 23 (6) ◽

pp. 672-678 ◽

Cited By ~ 2

Author(s):

Xuelin Zhou ◽

Wai Ping Lam ◽

Hong Chai Tang ◽

Chi-Man Koon ◽

Ling Cheng ◽

...

Keyword(s):

Detrusor Overactivity ◽

Spontaneously Hypertensive Rats ◽

Water Extract ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

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Diminished sympathetic silent period in spontaneously hypertensive rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1979.236.3.r147 ◽

1979 ◽

Vol 236 (3) ◽

pp. R147-R152 ◽

Cited By ~ 1

Author(s):

L. P. Schramm ◽

G. N. Barton

Keyword(s):

Electrical Stimulation ◽

Sympathetic Activity ◽

Spontaneously Hypertensive Rats ◽

Silent Period ◽

Spontaneous Hypertension ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Splanchnic Nerves ◽

Wistar Kyoto ◽

Stimulation Of

To determine if elevated sympathetic activity occurs in spontaneously hypertension, the silent period induced in splanchnic nerves following electrical stimulation of dorsal medullary sympathoexcitatory sites was compared in anesthetized normotensive Wistar Kyoto rats (WKYs) and Okamoto spontaneously hypertensive rats (SHRs). The strength of silent periods was defined as the degree of inhibition of responses to testing stimuli delivered at various latencies following conditioning trains, and it was assumed to be inversely related to the level of sympathetic activity. Weanling SHRs exhibited weaker silent periods than weanling WKYs although, at that age, the arterial pressures of the strains were not significantly different. Silent periods were also weaker in adult SHRs than in adult WKYs. This difference persisted after arterial pressures, which fell under anesthesia, were raised by phenylephrine infusions to the respective "normal" levels in each strain. These results support the hypothesis that elevated sympathetic activity exists during both the development and maintenance of spontaneous hypertension in rats.

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