scholarly journals Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling

2012 ◽  
Vol 16 (12) ◽  
pp. 2968-2977 ◽  
Author(s):  
Jun Yan ◽  
Bo Li ◽  
Jiang-Wei Chen ◽  
Sheng-Dan Jiang ◽  
Lei-Sheng Jiang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Wnt Signalling ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cord Injury ◽  
Injury Causes

Evidence for the Role of Peroxisome Proliferator-Activated Receptor-β/δ in the Development of Spinal Cord Injury

2010 ◽  
Vol 333 (2) ◽  
pp. 465-477 ◽  
Author(s):  
Irene Paterniti ◽  
Emanuela Esposito ◽  
Emanuela Mazzon ◽  
Maria Galuppo ◽  
Rosanna Di Paola ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cord Injury

scholarly journals Potential Therapeutic Targets for PPAR after Spinal Cord Injury

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Dana M. McTigue
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Death ◽  
Traumatic Injury ◽  
Therapeutic Targets ◽  
Great Promise ◽  
Peroxisome Proliferator ◽  
Cns Injury ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cord Injury

Traumatic injury to the spinal cord results in multiple anatomical, physiological, and functional deficits as a result of local neuronal and glial cell death as well as loss of descending and ascending axons traversing the injury site. The many different mechanisms thought to contribute to protracted secondary cell death and dysfunction after spinal cord injury (SCI) are potential therapeutic targets. Agents that bind and activate the transcription factor peroxisome proliferator-activated receptor- (PPAR-) show great promise for minimizing or preventing these deleterious cascades in other models of CNS disorders. This review will summarize the major secondary injury cascades occurring after SCI and discuss data from experimental CNS injury and disease models showing the exciting potential for PPAR therapies after SCI.

Progressive Sublesional Bone Loss Extends into the Second Decade After Spinal Cord Injury

2019 ◽  
Vol 22 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Christopher M. Cirnigliaro ◽  
Mary Jane Myslinski ◽  
Pierre Asselin ◽  
Joshua C. Hobson ◽  
Adam Specht ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Cord Injury

scholarly journals Prevention and Treatment of Bone Loss After a Spinal Cord Injury: A Systematic Review

2007 ◽  
Vol 13 (1) ◽  
pp. 123-145 ◽  
Author(s):  
Maureen Ashe ◽  
Catharine Craven ◽  
Janice Eng ◽  
Andrei Krassioukov
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Cord Injury ◽  
Prevention And Treatment
Sign in / Sign up

Export Citation Format

Share Document