Alterations in protein expression patterns of spinal peroxisome proliferator-activated receptors after spinal cord injury

2019 ◽  
Vol 41 (10) ◽  
pp. 883-892
Author(s):  
Youngkyung Kim ◽  
Kyu-Won Park ◽  
Jeonghwa Oh ◽  
Junesun Kim ◽  
Young Wook Yoon
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protein Expression ◽  
Expression Patterns ◽  
Peroxisome Proliferator ◽  
Cord Injury ◽  
Peroxisome Proliferator Activated Receptors

scholarly journals Decrease of PPARδin Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury

PPAR Research ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Cheng-Chia Tsai ◽  
Kung-Shing Lee ◽  
Sheng-Hsien Chen ◽  
Li-Jen Chen ◽  
Keng-Fan Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mortality Rate ◽  
Survival Rates ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Peroxisome Proliferator ◽  
Survival Times ◽  
Cord Injury ◽  
Peroxisome Proliferator Activated Receptors

Changes in the peroxisome proliferator-activated receptors-δ(PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPARδin SCI remains unknown. In the present study, we used compressive SCI in streptozotocin-(STZ-) induced diabetic rats. GW0742, a PPARδagonist, was used to evaluate its merit in STZ rats after SCI. Changes in PPARδexpression were detected by Western blot. Survival rates were also estimated. A lower expression of PPARδin spinal cords of STZ-diabetic rats was observed. In addition, the survival times in two-week induction diabetes were longer than those in eight-week induction group, which is consistent with the expression of PPARδin the spinal cord. Moreover, GW0742 significantly increased the survival time of STZ rats. Furthermore, their motor function and pain response were attenuated by GSK0660, a selective PPARδantagonist, but were enhanced by GW0742. In conclusion, the data suggest that higher mortality rate in STZ-diabetic rats with SCI is associated with the decrease of PPARδexpression. Thus, change of PPARδexpression with the progress of diabetes seems responsible for the higher mortality rate after SCI.

scholarly journals RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-14 ◽  
Author(s):  
Sabien van Neerven ◽  
Jörg Mey
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peroxisome Proliferator ◽  
Inflammatory Reactions ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Anti Inflammatory ◽  
Peroxisome Proliferator Activated Receptors ◽  
X Receptors ◽  
Physiological Reactions

The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experiments show how RAR signaling may improve axonal regeneration and modulate reactions of glia cells. While anti-inflammatory properties of PPAR are well documented in the periphery, their possible roles in the central nervous system have only recently become evident. Due to its anti-inflammatory function this transcription factor family promises to be a useful target after spinal cord or brain lesions.

Evidence for the Role of Peroxisome Proliferator-Activated Receptor-β/δ in the Development of Spinal Cord Injury

2010 ◽  
Vol 333 (2) ◽  
pp. 465-477 ◽  
Author(s):  
Irene Paterniti ◽  
Emanuela Esposito ◽  
Emanuela Mazzon ◽  
Maria Galuppo ◽  
Rosanna Di Paola ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cord Injury

scholarly journals Delayed inflammatory mRNA and protein expression after spinal cord injury

2011 ◽  
Vol 8 (1) ◽  
pp. 130 ◽  
Author(s):  
Kimberly R Byrnes ◽  
Patricia M Washington ◽  
Susan M Knoblach ◽  
Eric Hoffman ◽  
Alan I Faden
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protein Expression ◽  
Cord Injury ◽  
Mrna And Protein Expression

A Selective P2Y Purinergic Receptor Agonist 2-MesADP Enhances Locomotor Recovery after Acute Spinal Cord Injury

2020 ◽  
Vol 83 (2) ◽  
pp. 195-212
Author(s):  
Ziru Zhao ◽  
Xiao Hu ◽  
Zhourui Wu ◽  
Qi Chen ◽  
Qihui Shao
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Purinergic Receptor ◽  
Expression Patterns ◽  
Gene Profiling ◽  
Locomotor Recovery ◽  
Wnt Signal Pathway ◽  
Cord Injury

Introduction: Spinal cord injury (SCI) causes most severe motor and sensory dysfunctions. In Chinese traditional medicine, the agonist of a purinergic receptor is believed to have a positive effect on SCIs, and 2-Methylthio-adenosine-5′-diphosphate (2-MesADP) is a selective agonist of the P2Y purinergic receptor. Methods: To investigate its therapeutic function and molecular mechanism in SCI, transcriptome analysis associated with weighted gene co-expression network analysis (WGCNA) was carried out at various time points after T9 crush injury. Results: 2-MesADP demonstrated recovery of limb motor function at the 6 weeks after injury, accompanied by neuronal regeneration and axon remyelination at 2 and 6 weeks. Furthermore, gene profiling revealed alternated gene expression with the treatment of 2-MesADP. These genes were assigned to a total of 38 modules, followed by gene ontology analysis; of these, 18 represented neuronal apoptosis and regeneration, immune response, synaptic transmission, cell cycle, and angiogenesis. In the neuronal apoptosis and regeneration module, Nefh, NeuroD6, and Dcx in the 2-MesADP group were noticed due to their interesting expression pattern. The gene expression patterns of Mag, Mog, and Cnp, which played key roles in myelination, were significantly changed with the treatment of 2-MesADP. Wnt signal pathway was the most important pathway in 2-MesADP treatment for acute SCI. Conclusion: 2-MesADP enhanced locomotor recovery in mouse SCI by altering the expression of neuronal apoptosis and remyelination-related genes and Wnt signaling pathways.

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