A double-blind study on a patient with tardive dyskinesia treated with pallidal deep brain stimulation

2009 ◽  
Vol 119 (4) ◽  
pp. 269-273 ◽  
Author(s):  
Z. Kefalopoulou ◽  
A. Paschali ◽  
E. Markaki ◽  
P. Vassilakos ◽  
J. Ellul ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Tardive Dyskinesia ◽  
Brain Stimulation ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Seizure outcome after hippocampal deep brain stimulation in patients with refractory temporal lobe epilepsy: A prospective, controlled, randomized, double-blind study

Epilepsia ◽  
2017 ◽  
Vol 58 (10) ◽  
pp. 1728-1733 ◽  
Author(s):  
Arthur Cukiert ◽  
Cristine Mella Cukiert ◽  
Jose Augusto Burattini ◽  
Pedro Paulo Mariani ◽  
Daniela Fontes Bezerra
Keyword(s):  
Deep Brain Stimulation ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Brain Stimulation ◽  
Blind Study ◽  
Seizure Outcome ◽  
Double Blind Study ◽  
Double Blind ◽  
Deep Brain

scholarly journals A randomized double-blind crossover trial comparing subthalamic and pallidal deep brain stimulation for dystonia

2014 ◽  
Vol 120 (1) ◽  
pp. 295
Author(s):  
Lisbeth Schjerling ◽  
Lena E. Hjermind ◽  
Bo Jespersen ◽  
Flemming F. Madsen ◽  
Jannick Brennum ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Crossover Trial ◽  
Double Blind ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Anterior pallidal deep brain stimulation for Tourette's syndrome: a randomised, double-blind, controlled trial

2017 ◽  
Vol 16 (8) ◽  
pp. 610-619 ◽  
Author(s):  
Marie-Laure Welter ◽  
Jean-Luc Houeto ◽  
Stéphane Thobois ◽  
Benoit Bataille ◽  
Marc Guenot ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Controlled Trial ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Double Blind ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Both thalamic and pallidal deep brain stimulation for myoclonic dystonia

2010 ◽  
Vol 112 (6) ◽  
pp. 1267-1270 ◽  
Author(s):  
Jean Q. L. Oropilla ◽  
Cid C. E. Diesta ◽  
Parunut Itthimathin ◽  
Oksana Suchowersky ◽  
Zelma H. T. Kiss
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rating Scales ◽  
Surgical Intervention ◽  
Double Blind ◽  
Thalamic Stimulation ◽  
Pallidal Stimulation ◽  
Pars Interna ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

Myoclonic dystonia is poorly managed with medication and may be severe enough to warrant surgical intervention. Surgery has targeted either the globus pallidus pars interna (GPi) or the thalamus, but there is no accepted target for this condition. The authors present the case of a 23-year-old man treated with unilateral deep brain stimulation in both the thalamus and GPi. His movement disorder improved dramatically with stimulation. Two years postoperatively, the authors performed a double-blind assessment of the effects of each stimulator together, separately, and off stimulation. Videotape assessment, using tremor, dystonia, and myoclonus rating scales, showed that most of the benefit could be attributed to pallidal stimulation, although there was some advantage to stimulation at both sites. These results suggest that while GPi stimulation may be the better target for this condition, thalamic stimulation may be added in cases in which the benefit is insufficient.

scholarly journals CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study

2021 ◽  
pp. 1-13
Author(s):  
Gregor R. Wenzel ◽  
Jan Roediger ◽  
Christof Brücke ◽  
Ana Luísa de A. Marcelino ◽  
Eileen Gülke ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Clinical Effectiveness ◽  
Standard Of Care ◽  
Double Blind Study ◽  
Imaging Data ◽  
Double Blind ◽  
Entire Cohort ◽  
Reasonable Approach ◽  
Deep Brain

Background: Recent technological advances in deep brain stimulation (DBS) (e.g., directional leads, multiple independent current sources) lead to increasing DBS-optimization burden. Techniques to streamline and facilitate programming could leverage these innovations. Objective: We evaluated clinical effectiveness of algorithm-guided DBS-programming based on wearable-sensor-feedback compared to standard-of-care DBS-settings in a prospective, randomized, crossover, double-blind study in two German DBS centers. Methods: For 23 Parkinson’s disease patients with clinically effective DBS, new algorithm-guided DBS-settings were determined and compared to previously established standard-of-care DBS-settings using UPDRS-III and motion-sensor-assessment. Clinical and imaging data with lead-localizations were analyzed to evaluate characteristics of algorithm-derived programming compared to standard-of-care. Six different versions of the algorithm were evaluated during the study and 10 subjects programmed with uniform algorithm-version were analyzed as a subgroup. Results: Algorithm-guided and standard-of-care DBS-settings effectively reduced motor symptoms compared to off-stimulation-state. UPDRS-III scores were reduced significantly more with standard-of-care settings as compared to algorithm-guided programming with heterogenous algorithm versions in the entire cohort. A subgroup with the latest algorithm version showed no significant differences in UPDRS-III achieved by the two programming-methods. Comparing active contacts in standard-of-care and algorithm-guided DBS-settings, contacts in the latter had larger location variability and were farther away from a literature-based optimal stimulation target. Conclusion: Algorithm-guided programming may be a reasonable approach to replace monopolar review, enable less trained health-professionals to achieve satisfactory DBS-programming results, or potentially reduce time needed for programming. Larger studies and further improvements of algorithm-guided programming are needed to confirm these results.

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