Correlation between optic nerve fibre polarimetry and automated perimetry in primary open-angle glaucoma

Abstract Purpose To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% ± 3.57% vs. 34.92% ± 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% ± 3.04% vs. 42.09% ± 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm2 ± 0.1 mm2 vs. 0.23 mm2 ± 0.09 mm2) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% ± 1.11% vs. 33.35% ± 0.95%, p = 0.194) and peripapillary plexus PD (46.65% ± 0.83% vs. 46.95% ± 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.

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Assessment of the development of primary open-angle glaucoma and diabetic retinopathy using digital medicine

E3S Web of Conferences ◽

10.1051/e3sconf/202022403022 ◽

2020 ◽

Vol 224 ◽

pp. 03022

Author(s):

I V Vorobyeva

Keyword(s):

Diabetic Retinopathy ◽

Optic Nerve ◽

Optic Nerve Head ◽

Primary Open Angle Glaucoma ◽

Low Vision ◽

Open Angle Glaucoma ◽

Digital Data ◽

Open Angle ◽

Neuroretinal Rim ◽

Digital Medicine

The leading place in the structure of blindness and low vision is occupied by two diseases: primary open-angle glaucoma and diabetic retinopathy. The combination of two diseases in one eye gives an even more severe prognosis for vision. Modern diagnostic equipment helps in accurate and early diagnosis of the disease by analyzing digital data of the optic nerve head and macular area of the retina according to the results of an optical coherence tomograph. A mathematical model for predicting the development of diabetic retinopathy and primary open-angle glaucoma according to the proposed mathematical criteria has been developed. The criteria represent the ratio of the integral area of the neuroretinal rim to the integral volume of the neuroretinal rim; the retinal thickness criterion and criterion of the primary open-angle glaucoma and diabetic retinopathy are calculated. A computer program has been developed. The algorithm of the program, which includes windows for entering digital data of the macular zone and parameters of the optic nerve head, is presented. The result of the program is the statement of the risk of developing combined pathology of the fundus in a particular patient.

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