54. SIMPLE AND RAPID EVALUATION OF THE INTRAVASCULAR COAGULATION AND FIBRINOLYTIC STATES BY APPLICATION OF PROTAMINE SULPHATE AND REPTILASE R

2009 ◽  
Vol 8 (S13) ◽  
pp. 387-388
Author(s):  
Z.S. Latallo ◽  
Z. Wegrzynowicz ◽  
E. Teisseyre ◽  
Maria Kopeć
Keyword(s):  
Rapid Evaluation ◽  
Protamine Sulphate ◽  
Intravascular Coagulation

Disseminated Intravascular Coagulation During Severe Diseases in 0–12 Months old Children (Study on 54 Cases)

1975 ◽  
Author(s):  
E. Coeugniet
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Clinical Symptoms ◽  
Laboratory Diagnosis ◽  
Critical Periods ◽  
Protamine Sulphate ◽  
Intravascular Coagulation ◽  
Gram Positive Bacteria ◽  
K Deficiency ◽  
Severe Infections ◽  
Rapid Laboratory

Disseminated intravascular coagulation (DIC) occured during severe infections with: gram-negative bacteria (24 cases), gram-positive bacteria (3 cases), acute hemolysis (11 cases), pneumonias with hypoxic syndrome (16 cases). Adjuvant factors: Hypo-volaemia and metabolic acidosis (34 cases), malnutrition and hypoproteinaemia (32 cases). 38 patients were boys. Early clinical symptoms: alteration of the general state, impossibility of blood collectings because of hypercoagulability, bleeding after injections, haematemesis, melena, purpura, renal failure. Rapid laboratory diagnosis: ethanol test, paracoagulation with protamine sulphate, decrease of thrombocytes number, thrombin clotting time. The most important differential diagnosis is hypoprothrombinaenra by vit. K deficiency or by liver failure which could also complicate DIC (6 cases). During “critical” periods of diseases usually complicated by DIC the DIC prophylaxis is proposed (heparin 100–200 i.u./kg/day i.v. + dipyridamole 5 mg/kg/day i.v. or orally. The treatment of DIC: heparin 1000 i.u./kg/day i.v. or, in order to decrease the risk of secondary bleedings because of heparin an association: heparin 400 i.u./kg day i.v. + dipyridamole 5—10 mg/kg/day i.v. or orally.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Fibrin Derivatives, Plasma Hemoglobin and Glomerular Fibrin Deposition in Experimental Intravascular Coagulation

1973 ◽  
Vol 29 (02) ◽  
pp. 363-374 ◽  
Author(s):  
F. K Beller ◽  
W Theiss
Keyword(s):  
Quantitative Measurement ◽  
Plasma Fibrinogen ◽  
Moderate Increase ◽  
Consumption Coagulopathy ◽  
Fibrin Deposition ◽  
Intravascular Coagulation ◽  
Plasma Hemoglobin ◽  
Three Stages ◽  
Two Parameters ◽  
Gelation Test

SummaryPlasma fibrinogen, circulating fibrinmonomers (as indicated by a positive ethanol gelation test), fibrinolysis breakdown products and plasma hemoglobin were assayed in 122 rats subjected to endotoxin injection or infusion. The results were correlated with the quantitative measurement of glomerular fibrin deposition. Based on these data four groups were determined : consumption coagulopathy and three stages of increasing severity of disseminated intravascular coagulation (DIG).Consumption coagulopathy was defined by a decrease in plasma fibrinogen and a positive ethanol gelation test in the absence of glomerular fibrin deposition. Plasma hemoglobin and fibrinolysis breakdown products were normal or only slightly increased.DIG as characterized by glomerular fibrin deposition was defined as moderate (1 to 20% glomeruli showing fibrin strands), intermediate (21 to 80%), and severe (81 to 100%). Decrease in plasma fibrinogen and frequence of a positive ethanol gelation test in all stages of DIG were only slightly different from the findings in consumption coagulopathy. However, a sharp increase in plasma hemoglobin levels was noted when glomerular fibrin deposition did occur even in small amounts. At this time only a moderate increase was noted in fibrin(ogen) breakdown products. These two parameters increased only slightly in the group of intermediate DIG. Severe DIG was characterized by a massive increase in fibrin (ogen) breakdown products and high levels of plasma hemoglobin.

Relationship Between Fibrinopeptide A and Fibrinogen/Fibrin Fragment E in Thromboembolism, DIC and Various Non-Thromboembolic Diseases

1987 ◽  
Vol 58 (02) ◽  
pp. 758-763 ◽  
Author(s):  
G Mombelli ◽  
R Monotti ◽  
A Haeberli ◽  
P W Straub
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Liver Cirrhosis ◽  
Healthy Subjects ◽  
Vascular Diseases ◽  
Fibrinopeptide A ◽  
Normal Range ◽  
Collagen Vascular Diseases ◽  
Intravascular Coagulation ◽  
Fibrin Formation

SummaryIncreased fibrinopeptide A (FPA) levels have been reported in various non-thrombotic disorders, including cancer, acute myocardial infarction, liver cirrhosis and collagen vascular diseases. To investigate the significance of these findings, the present study combined the radioimmunoassay of FPA with that of fibrinogen/fibrin degradation fragment E (FgE) in the aforementioned disorders and compared the results with those observed in healthy subjects as well as in patients with thromboembolism and overt disseminated intravascular coagulation (DIC). Mean FPA and FgE in malignancy were 6.3 and 305 ng/ml, in myocardial infarction 5.6 and 98 ng/ml, in liver cirrhosis 2.7 and 132 ng/ml and in collagen vascular diseases 5.6 and 142 ng/ml. All these values were significantly higher than in healthy controls (mean FPA 1.6 ng/ml, mean FgE 49 ng/ml) but significantly lower than in thromboembolism (mean FPA 10.7 ng/ml, mean FgE 639 ng/ ml) and DIC (mean FPA 22.0 ng/ml, mean FgE 1041 ng/ml). The overall correlation between FPA and FgE was highly significant. Elowever, different disorders showed peculiar patterns in FPA, FgE and fibrinogen levels. In malignancy, a definite increase of FPA, FgE and plasma fibrinogen levels was observed. This finding probably indicates a compensated state of (intra- or extravascular) fibrin formation and lysis. Acute myocardial infarction was characterized by a high FPA to FgE ratio, which is interpreted to reflect acute thrombin generation and fibrin formation. FPA in cirrhosis was only marginally elevated with most single values within the normal range, indicating that intravascular coagulation was infrequent and unimportant in quantitative terms.

Plasma Thrombin Assay using a Chromogenic Substrate in Disseminated Intravascular Coagulation due to Snake Bite Envenomation

1979 ◽  
Vol 41 (03) ◽  
pp. 544-552 ◽  
Author(s):  
R P Herrmann ◽  
P E Bailey
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Degradation Products ◽  
Snake Bite ◽  
Chromogenic Substrate ◽  
Coagulation Parameters ◽  
Fibrinogen Degradation Products ◽  
Intravascular Coagulation

SummaryUsing the chromogenic substrate, Tos-Gly-Pro-Arg-pNA-HCL (Chromozym TH, Boehringer Mannheim) plasma thrombin was estimated in six cases of envenomation by Australian elapid snakes. All patients manifested findings chracteristic of defibrination due to envenomation by these snakes. Fibrin-fibrinogen degradation products were grossly elevated, as was plasma thrombin in all cases.Following treatment with antivenene, all abnormal coagulation parameters returned rapidly towards normal by 24 hours and plasma thrombin disappeared.

Reticuloendothelial Function and Blood Coagulation in Rats

1969 ◽  
Vol 22 (03) ◽  
pp. 508-512
Author(s):  
L Pechet ◽  
Giselle S. Pechet ◽  
R. A MacDonald
Keyword(s):  
Blood Coagulation ◽  
Free Carbon ◽  
Colloidal Iron ◽  
Intravascular Coagulation ◽  
India Ink ◽  
Carbon Clearance

SummaryIntravascular coagulation and its possible effect on carbon clearance was studied in rats following the injection of commercial india ink containing shellac; a shellac-free carbon preparation; gelatin; heat denatured albumin; colloidal iron; and heparin. No relationship was found between activation of coagulation and RES function as measured by clearance of intravenously injected carbon.

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