Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens

2007 ◽  
Vol 215 (1) ◽  
pp. 59-76 ◽  
Author(s):  
Craig T. Morita ◽  
Chenggang Jin ◽  
Ghanashyam Sarikonda ◽  
Hong Wang
Keyword(s):  
T Cells ◽  
Immunological Memory ◽  
Nonpeptide Antigens ◽  
Vγ2vδ2 T Cells ◽  
Prenyl Pyrophosphate

scholarly journals Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

2013 ◽  
Vol 191 (3) ◽  
pp. 1029-1042 ◽  
Author(s):  
Hong Wang ◽  
Olivier Henry ◽  
Mark D. Distefano ◽  
Yen-Chih Wang ◽  
Johanna Räikkönen ◽  
...  
Keyword(s):  
T Cells ◽  
Essential Role ◽  
Vγ2vδ2 T Cells ◽  
Prenyl Pyrophosphate ◽  
Stimulation Of

scholarly journals Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3578
Author(s):  
Emilie Barsac ◽  
Carolina de Amat Herbozo ◽  
Loïc Gonzalez ◽  
Thomas Baranek ◽  
Thierry Mallevaey ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Immunity ◽  
Cell Biology ◽  
Therapeutic Potential ◽  
Γδ T Cells ◽  
Feasibility Studies ◽  
T Cell Subsets ◽  
Mait Cells ◽  
Nonpeptide Antigens

The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.

scholarly journals Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Mohanad H. Nada ◽  
Hong Wang ◽  
Grefachew Workalemahu ◽  
Yoshimasa Tanaka ◽  
Craig T. Morita
Keyword(s):  
T Cells ◽  
Cancer Immunotherapy ◽  
Vγ2vδ2 T Cells

scholarly journals Turning immunological memory into amnesia by depletion of dividing T cells

2003 ◽  
Vol 100 (25) ◽  
pp. 15017-15022 ◽  
Author(s):  
B. Bellier ◽  
V. Thomas-Vaslin ◽  
M.-F. Saron ◽  
D. Klatzmann
Keyword(s):  
T Cells ◽  
Immunological Memory

scholarly journals Inducible chromatin priming is associated with the establishment of immunological memory in T cells

2016 ◽  
Vol 35 (5) ◽  
pp. 515-535 ◽  
Author(s):  
Sarah L Bevington ◽  
Pierre Cauchy ◽  
Jason Piper ◽  
Elisabeth Bertrand ◽  
Naveen Lalli ◽  
...  
Keyword(s):  
T Cells ◽  
Immunological Memory

scholarly journals Association between Vγ2Vδ2 T Cells and Disease Progression after Infection with Closely Related Strains of HIV in China

2008 ◽  
Vol 46 (9) ◽  
pp. 1466-1472 ◽  
Author(s):  
Haishan Li ◽  
Hong Peng ◽  
Pengfei Ma ◽  
Yuhua Ruan ◽  
Bing Su ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Vγ2vδ2 T Cells

scholarly journals Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

2004 ◽  
Vol 113 (5) ◽  
pp. 701-708 ◽  
Author(s):  
Robert E. Hunger ◽  
Peter A. Sieling ◽  
Maria Teresa Ochoa ◽  
Makoto Sugaya ◽  
Anne E. Burdick ◽  
...  
Keyword(s):  
T Cells ◽  
Langerhans Cells ◽  
Nonpeptide Antigens
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