Saliva composition and caries development during protein deficiency and beta-receptor stimulation or inhibition

1987 ◽  
Vol 16 (3) ◽  
pp. 145-149 ◽  
Author(s):  
I. Johansson ◽  
T. Ericson
Keyword(s):  
Protein Deficiency ◽  
Receptor Stimulation ◽  
Beta Receptor ◽  
Saliva Composition

Electrophysiological analysis of beta-receptor stimulation in salamander proximal tubules

1987 ◽  
Vol 253 (4) ◽  
pp. F636-F641
Author(s):  
N. S. Morgunov
Keyword(s):  
Basolateral Membrane ◽  
Membrane Resistance ◽  
Proximal Tubules ◽  
Sodium Reabsorption ◽  
Organic Substrates ◽  
Receptor Stimulation ◽  
Electrophysiological Response ◽  
Control Value ◽  
Beta Receptor ◽  
Absolute Requirement

Electrophysiological response to isoproterenol stimulation was studied in isolated perfused salamander proximal tubules. The addition of 10(-5) M isoproterenol to the bath superfusate depolarized both the cell membrane, and transepithelial potentials by 2.2 +/- 0.2 and 0.31 +/- 0.04 mV, respectively (P less than 0.01, n = 35) and significantly reduced the apical-to-basolateral membrane resistance ratio by 30% (P less than 0.01, n = 7) from a control value of 3.7 +/- 0.6. These responses were blocked by 10(-6) M propranolol but not mimicked by 10(-4) M adenosine 3',5'-cyclic monophosphate. Qualitatively similar effects were observed with 10(-3) and 10(-7) M isoproterenol. Further characterization of the 10(-5) M isoproterenol response revealed 1) a 50% reduction in the response following the removal of organic substrates from the luminal perfusate, 2) an absolute requirement for sodium, and 3) an absolute requirement for a functioning basolateral Na+-K+-ATPase. The data suggest that beta-receptor stimulation may increase sodium reabsorption by activating sodium cotransport systems.

Cardiovascular responsiveness to beta-receptor stimulation in essential hypertension with cardiac hypertrophy

1987 ◽  
Vol 21 (2-3) ◽  
pp. 256
Author(s):  
Takeshi Ishide ◽  
Toshihiro Saito ◽  
Kazuo Noda ◽  
Masashi Takahashi ◽  
Akira Nakayama ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Cardiac Hypertrophy ◽  
Receptor Stimulation ◽  
Beta Receptor
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