A Comparison of Effects of BAY K 8644 and CGP 28392, Dihydropyridines with Ca Agonistic Properties, on Spontaneous Mechanical Activity in Rat Portal Vein: Modification of Effect by Ultraviolet Radiation

2009 ◽  
Vol 57 (5) ◽  
pp. 340-344 ◽  
Author(s):  
Erich O. Mikkelsen ◽  
Niels C. B. Nyborg ◽  
Preben Jakobsen
1996 ◽  
Vol 119 (4) ◽  
pp. 691-701 ◽  
Author(s):  
Gillian Edwards ◽  
Peter M. Zygmunt ◽  
Edward D. Högestätt ◽  
Arthur H. Weston

1990 ◽  
Vol 415 (5) ◽  
pp. 526-532 ◽  
Author(s):  
K. Nakao ◽  
Y. Inoue ◽  
M. Oike ◽  
K. Kitamura ◽  
H. Kuriyama

1974 ◽  
Vol 11 (5-6) ◽  
pp. 245-259 ◽  
Author(s):  
Bengt Uvelius ◽  
Stefan B. Sigurdsson ◽  
Börje Johansson

1985 ◽  
Vol 63 (4) ◽  
pp. 283-286
Author(s):  
J. L. Lacuara ◽  
R. D. Ruiz ◽  
M. Fiol de Cuneo

The effects of piretanide upon mechanical activity and pharmacological reactivity of vascular and myocardial tissues from normotensive rats were investigated. Magnitude of phasic contractions of isolated rat portal vein was diminished by the drug in a dose-related manner; contractile depression induced by piretanide (10−4 M) was less in the presence of insulin (0.1 U/mL), glucose (22 mM) or pyruvate (5 mM). Responses to KCl (90 mM), or norepinephrine (2.5 × 10−5 M) were also reduced. Contractile activity of atria and ventricle strips was diminished only when piretanide reached 10−4 M. Results support direct actions of piretanide upon cardiac and vascular tissues. Possible mechanisms of action are discussed.


1967 ◽  
Vol 21 (5) ◽  
pp. 609-618 ◽  
Author(s):  
JOHANN AXELSSON ◽  
BO WAHLSTROöm ◽  
Börje JOHANSSON ◽  
OLOF JONSSON

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