Human immunodeficiency virus-positive individuals with oral hairy leukoplakia are able to mount cytotoxic T lymphocyte responses to Epstein-Barr virus

Oral Diseases ◽  
2008 ◽  
Vol 6 (1) ◽  
pp. 40-47 ◽  
Author(s):  
A Jong ◽  
JM Palefsky ◽  
DP Stites ◽  
M Nakagawa
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Epstein Barr Virus ◽  
Cytotoxic T Lymphocyte ◽  
Barr Virus ◽  
Oral Hairy Leukoplakia ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Lymphocyte Responses

Epstein-Barr Virus Coinfection and Recombination in Non-Human Immunodeficiency Virus-Associated Oral Hairy Leukoplakia

1995 ◽  
Vol 171 (5) ◽  
pp. 1122-1130 ◽  
Author(s):  
D. M. Walling ◽  
N. M. Clark ◽  
D. M. Markovitz ◽  
T. S. Frank ◽  
D. K. Braun ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Oral Hairy Leukoplakia ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Cytotoxic T lymphocyte responses to Epstein-Barr virus

1996 ◽  
Vol 8 (4) ◽  
pp. 492-497 ◽  
Author(s):  
Alan B Rickinson ◽  
Steven P Lee ◽  
Neil M Steven
Keyword(s):  
T Lymphocyte ◽  
Epstein Barr Virus ◽  
Cytotoxic T Lymphocyte ◽  
Barr Virus ◽  
Epstein Barr ◽  
Lymphocyte Responses

scholarly journals Identification of type B-specific and cross-reactive cytotoxic T-lymphocyte responses to Epstein-Barr virus.

1996 ◽  
Vol 70 (12) ◽  
pp. 8858-8864 ◽  
Author(s):  
B M Kerr ◽  
N Kienzle ◽  
J M Burrows ◽  
S Cross ◽  
S L Silins ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Epstein Barr Virus ◽  
Cytotoxic T Lymphocyte ◽  
Type B ◽  
Barr Virus ◽  
Epstein Barr ◽  
Lymphocyte Responses

scholarly journals Coinfection with multiple strains of the Epstein-Barr virus in human immunodeficiency virus-associated hairy leukoplakia.

1992 ◽  
Vol 89 (14) ◽  
pp. 6560-6564 ◽  
Author(s):  
D. M. Walling ◽  
S. N. Edmiston ◽  
J. W. Sixbey ◽  
M. Abdel-Hamid ◽  
L. Resnick ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Multiple Strains

scholarly journals Epstein-Barr virus-related oral T-cell lymphoma associated with human immunodeficiency virus immunosuppression

Blood ◽  
1993 ◽  
Vol 81 (12) ◽  
pp. 3350-3356 ◽  
Author(s):  
JA Thomas ◽  
F Cotter ◽  
AM Hanby ◽  
LQ Long ◽  
PR Morgan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Epstein-Barr virus (EBV) is generally held to infect B cells and epithelial cells, although there are now reports of EBV infection in normal T cells and neoplastic T-cell diseases. In patients with human immunodeficiency virus (HIV) infection, EBV is associated with the benign epithelial lesion, hairy leukoplakia, and has been reported in up to 80% of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma. This study shows the presence of EBV in malignant oral T-cell lymphoma in three AIDS patients, two of whom had concurrent manifestation of hairy leukoplakia. The T-cell lineage of the tumor cells was determined by positive immunophenotyping for T-cell markers and lack of B-cell or nonhematopoietic (cytokeratin) determinants. All tumors contained monoclonal T-cell populations shown by polymerase chain reaction, which showed amplification of T-cell receptor gamma chain DNA without evidence of Ig heavy chain gene rearrangement. Furthermore, these lesions showed the presence of EBV DNA and expression of EBV latent gene products in the tumor cells. EBV involvement in AIDS-related T-cell lymphoma has not been widely reported and may represent a further manifestation of opportunistic EBV infection arising in the HIV-immunocompromised host.

scholarly journals Epstein-Barr virus-related oral T-cell lymphoma associated with human immunodeficiency virus immunosuppression

Blood ◽  
1993 ◽  
Vol 81 (12) ◽  
pp. 3350-3356 ◽  
Author(s):  
JA Thomas ◽  
F Cotter ◽  
AM Hanby ◽  
LQ Long ◽  
PR Morgan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hairy Leukoplakia ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Abstract Epstein-Barr virus (EBV) is generally held to infect B cells and epithelial cells, although there are now reports of EBV infection in normal T cells and neoplastic T-cell diseases. In patients with human immunodeficiency virus (HIV) infection, EBV is associated with the benign epithelial lesion, hairy leukoplakia, and has been reported in up to 80% of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphoma. This study shows the presence of EBV in malignant oral T-cell lymphoma in three AIDS patients, two of whom had concurrent manifestation of hairy leukoplakia. The T-cell lineage of the tumor cells was determined by positive immunophenotyping for T-cell markers and lack of B-cell or nonhematopoietic (cytokeratin) determinants. All tumors contained monoclonal T-cell populations shown by polymerase chain reaction, which showed amplification of T-cell receptor gamma chain DNA without evidence of Ig heavy chain gene rearrangement. Furthermore, these lesions showed the presence of EBV DNA and expression of EBV latent gene products in the tumor cells. EBV involvement in AIDS-related T-cell lymphoma has not been widely reported and may represent a further manifestation of opportunistic EBV infection arising in the HIV-immunocompromised host.

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