Trichoblastomas with Merkel cell proliferation in nevi sebacei in Schimmelpenning-Feuerstein-Mims syndrome – Histological differentiation between trichoblastomas and basal cell carcinomas

2009 ◽  
Vol 7 (7) ◽  
pp. 612-614 ◽  
Author(s):  
Katharina Wiedemeyer ◽  
Wolfgang Hartschuh
Keyword(s):  
Cell Proliferation ◽  
Basal Cell ◽  
Merkel Cell ◽  
Histological Differentiation ◽  
Basal Cell Carcinomas

The expression of p63 in basal cell carcinomas and association with histological differentiation

2006 ◽  
Vol 33 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Sema Bircan ◽  
Ozden Candir ◽  
Nilgun Kapucoglu ◽  
Sirin Baspinar
Keyword(s):  
Basal Cell ◽  
Histological Differentiation ◽  
Basal Cell Carcinomas

Merkel cell polyomavirus in naevoid basal cell carcinoma syndrome-associated basal cell carcinomas and sporadic trichoblastomas

2010 ◽  
Vol 59 (2) ◽  
pp. 140-142 ◽  
Author(s):  
Ahmad Kassem ◽  
Deepa Pantulu ◽  
Kristin Technau ◽  
Anna Kordelia Kurz ◽  
Carlos Diaz ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Basal Cell Carcinomas

scholarly journals MTOR promotes basal cell carcinoma growth through atypical PKC

2020 ◽  
Author(s):  
Rachel Y. Chow ◽  
Taylor M. Levee ◽  
Gurleen Kaur ◽  
Daniel P. Cedeno ◽  
Linda T. Doan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Basal Cell Carcinoma ◽  
Tumor Growth ◽  
Basal Cell ◽  
Sequencing Analysis ◽  
Promising Target ◽  
Basal Cell Carcinomas ◽  
Hh Signaling ◽  
Human And Mouse ◽  
Mtor Activity

ABSTRACTAdvanced basal cell carcinomas (BCCs) are driven by the Hedgehog (HH) pathway and often possess inherent resistance to SMO inhibitors. Identifying and targeting pathways that bypass SMO could provide alternative treatments. Here, we use a combination of RNA-sequencing analysis of advanced BCC tumor-normal pairs and immunostaining of human and mouse BCC samples to identify an MTOR signature in BCC. Pharmacological inhibition of MTOR activity in BCC cells significantly reduces cell proliferation without affecting HH signaling. Similarly, treatment of Ptch1fl/fl; Gli1-CreERT2 mice with everolimus reduces tumor growth and aPKC activity, suggesting that MTOR promotes tumor growth by activating aPKC and demonstrating that suppressing MTOR could be a promising target for BCC patients.

scholarly journals Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma

2013 ◽  
Vol 5 ◽  
pp. BIC.S11856 ◽  
Author(s):  
Bahar Dasgeb ◽  
Tarana M Mohammadi ◽  
Darius R Mehregan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Specific Antigen ◽  
Squamous Cell Carcinomas ◽  
Positive Staining ◽  
Merkel Cell ◽  
Diagnostic Pitfall ◽  
Basal Cell Carcinomas

EpCam is a transmembrane epithelial adhesion molecule present on all non-squamous epithelial cells. It is often overexpressed in certain carcinomas, such as breast and colon, and in dermatology, eg, basal cell carcinoma (BCC). Various monoclonal antibodies have been used to detect EpCam, including BerEP4 and epithelial specific antigen. We compared anti-EpCam clones, BerEP4, and epithelial specific antigen clone VU-1D9. One hundred and twelve lesions were stained with both antibodies. All basal cell carcinomas stained uniformly and strongly positive with both antibodies. Diffuse positive staining was also seen in all trichoepitheliomas and merkel cell carcinomas. Focal positive staining was seen in squamous cell carcinoma and benign sebaceous neoplasms. Clone VU-1D9 was more likely to produce focal positive staining as compared to BerEP4. This focal positive staining of sebaceous neoplasms and squamous cell carcinomas is a potential diagnostic pitfall.

Scalpel excision of basal cell carcinomas

1978 ◽  
Vol 114 (5) ◽  
pp. 739-742 ◽  
Author(s):  
R. S. Bart
Keyword(s):  
Basal Cell ◽  
Basal Cell Carcinomas

Follicular atrophoderma with multiple basal cell carcinomas. An abortive form of bazex syndrome.

1989 ◽  
Vol 51 (2) ◽  
pp. 250-255
Author(s):  
Seiji ARASE ◽  
Hideki NAKANISHI ◽  
Shin HARADA ◽  
Fumio SHIGEMI ◽  
Katsuyuki TAKEDA
Keyword(s):  
Basal Cell ◽  
Basal Cell Carcinomas ◽  
Multiple Basal Cell Carcinomas
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