Diagnostic value of monoclonal antibody B72.3 in detecting adenocarcinoma cells in serous effusions

Apmis ◽  
1989 ◽  
Vol 97 (7-12) ◽  
pp. 761-766 ◽  
Author(s):  
ANNE F. LAURITZEN
Keyword(s):  
Monoclonal Antibody ◽  
Diagnostic Value ◽  
Adenocarcinoma Cells ◽  
Monoclonal Antibody B72.3

A radioimmunoassay for the detection of a human tumor-associated glycoprotein (tag-72) using monoclonal antibody B72.3

1986 ◽  
Vol 37 (5) ◽  
pp. 659-666 ◽  
Author(s):  
Andrew J. Paterson ◽  
Jeffrey Schlom ◽  
Henry F. Sears ◽  
Jeffrey Bennett ◽  
David Colcher
Keyword(s):  
Monoclonal Antibody ◽  
Human Tumor ◽  
Monoclonal Antibody B72.3

scholarly journals A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells

2015 ◽  
Vol 46 (4) ◽  
pp. 1781-1787 ◽  
Author(s):  
YUKARI NISHII ◽  
MIKI YAMAGUCHI ◽  
YASUTOSHI KIMURA ◽  
TADASHI HASEGAWA ◽  
HIROYUKI ABURATANI ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cells

Compartmental analysis of the pharmacokinetics of radioiodinated monoclonal antibody B72.3 in colon cancer patients

1993 ◽  
Vol 20 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Raymond M. Reilly ◽  
Joel Kirsh ◽  
Steven Gallinger ◽  
Jake J. Thiessen ◽  
Manzur Damani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer ◽  
Cancer Patients ◽  
Compartmental Analysis ◽  
Monoclonal Antibody B72.3

Enhancement of Tumor Contrast on Radioimmunoscans by Using Mixtures of Monoclonal Antibody F(ab’)2 Fragments

1986 ◽  
Vol 25 (06) ◽  
pp. 216-219 ◽  
Author(s):  
A. Alavi ◽  
H. Koprowski ◽  
D. Herlyn ◽  
D. L. Munz
Keyword(s):  
Monoclonal Antibody ◽  
Gastrointestinal Tract ◽  
Nude Mice ◽  
Half Life ◽  
The Body ◽  
Whole Body ◽  
Antigenic Determinants ◽  
Body Images ◽  
Biological Half Life ◽  
Adenocarcinoma Cells

F(ab’)2 fragments of MAbs GA 73-3 (IgG 2a) and CO 29.11 (IgG 1), which detect distinct antigenic determinants on adenocarcinoma cells of the gastrointestinal tract, were labeled with 131I using the iodogen method. 41 nude mice bearing SW-948 CRC tumors were injected either with a mixture of 100 ¼Ci (11 ¼g) each (n = 9) of the two 131l-F(ab’)2 fragments or with either fragment alone at various doses (each group consisting of 8 mice): GA 73-3,100 ¼Ci (11 ¼g) and 200 ¼Ci (25 ¼g); CO 29.11,100 ¼Ci (11 ¼g) and 200 ¼Ci (26 ¼g). Whole-body images of the mice were obtained daily for up to six days after injection. Ratios of cpm/pixel in the tumor to those in the rest of the body (rob), representing tumor contrast, were significantly (p <0.05) higher in the group of mice injected with the mixture (3.9 ± 1.5) as compared to those given 100 or 200 jiCi of either fragment separately. The biological half-life (T1/2 biol) of the mixture (44.7 ± 14.5 h) in the CRC tumors was significantly (p <0.05) longer than T1/2 biol determined in the groups given either fragment alone. Tv bioL in the rob was similar in all groups of mice examined.

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