Human Acellular Matrix Graft of Tunica Albuginea for Penile Reconstruction

Penile fracture is an uncommon urological emergency, especially in Bangladesh. The other name is traumatic rupture of the tunica albuginea and corpora cavernosa in the erect penis. It occurs when an erect penis face to buckle under the pressure of a blunt sexual trauma. Patient gives the typical history of immediate detumescence, severe pain, swelling and eggplant deformity of the penile shaft due to penile injury. Immediate surgical exploration and repair of corpora Cavernosa with tunica albugenia is the most effective treatment modality. In normal cases diagnosis is made from history, physical examination alone. In some special cases ultrasonogram, radiological images, including retrograde urethrography or cavernosography are mandatory for proper diagnosis. KYAMC Journal Vol. 10, No.-2, July 2019, Page 122-125

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The Effect of PDE5 Inhibitors on the Male Reproductive Tract

Current Pharmaceutical Design ◽

10.2174/1381612826666200226121510 ◽

2020 ◽

Vol 26 ◽

Cited By ~ 2

Author(s):

Nikolaos Sofikitis ◽

Aris Kaltsas ◽

Fotios Dimitriadis ◽

Jens Rassweiler ◽

Nikolaos Grivas ◽

...

Keyword(s):

Male Infertility ◽

Reproductive Tract ◽

Tunica Albuginea ◽

Scientific Data ◽

Secretory Function ◽

Pde5 Inhibitors ◽

Male Reproductive Tract ◽

Review Study ◽

Phosphodiesterase 5

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

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Electrospun PLGA and PLGA/gelatin scaffolds for tubularized urethral replacement: Studies in vitro and in vivo

Journal of Biomaterials Applications ◽

10.1177/08853282211030904 ◽

2021 ◽

pp. 088532822110309

Author(s):

Jinhua Hu ◽

Bin Ai ◽

Shibo Zhu ◽

Zhen Wang ◽

Huimin Xia ◽

...

Keyword(s):

Tensile Deformation ◽

Canine Model ◽

Urothelial Cells ◽

Acellular Matrix ◽

Urethral Strictures ◽

Acid Copolymer ◽

Hematoxylin Eosin ◽

Collagen Tissue

To investigate the biocompatibility of polylactic acid-glycolic acid copolymer (PLGA) and PLGA/gelatin scaffolds and their suitability for tubular urethral replacement in a canine model. PLGA and PLGA/gelatin scaffolds was constructed by electrospinning. Microstructural differences between the scaffolds was examined by Scanning electron microscopy (SEM) followed by mechanical properties testing. Biocompatibility of the material was evaluated using SEM 4, 8, 12 and 72 h after PLGA and PLGA/gelatin scaffolds co-culture with urothelial cells. And confocal analysis was also used to showed the cell adhesive and growth at 12 h. Approximately 2 cm of the anterior urethra of twelve dogs were removed and replaced with a scaffold. After the surgery for 1 month performed urethrography and for 3 month perform hematoxylin–eosin (H&E) and Masson. The results indicated that PLGA and PLGA/gelatin scaffolds had a void microfilament structure, similar to that of normal acellular matrix tissue. And the tensile strength was decreased whereas the tensile deformation and suture retention strength was increased in PLGA/gelatin scaffolds compared to that in PLGA scaffolds Urothelial cells grew well on both scaffolds. Postoperatively, animals recovered well and urinated spontaneously. However, urethrography showed varying degrees of urethral strictures in the reconstructed urethras. H&E and Masson showed that multilayer urothelial cells were formed in both the proximal and distal segments of the reconstructed urethras but without continuity. There was a small amount of smooth muscle and blood vessels under the epithelium, but regenerative urothelial cells at the midpoint of the reconstructed segment did not continue. Lots of lymphocyte infiltration was observed under the epithelium, some collagen tissue was deposited under the neo-urethral epithelium were observed. In conclusion, PLGA and PLGA/gelatin scaffolds are not suitable for tubularized urethral replacement in the canine model.

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The Thickness and Density of the Ovarian Tunica Albuginea Increases with Age in Transgender Patients

Reproductive Sciences ◽

10.1007/s43032-020-00390-5 ◽

2021 ◽

Author(s):

Pilar Ferré-Pujol ◽

Junko Otsuki ◽

Hiroaki Funahashi ◽

Mikiya Nakatsuka

Keyword(s):

Tunica Albuginea

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Initial experience in the treatment of Peyronie’s disease using testicular vaginal tunica graft

Journal of Clinical Urology ◽

10.1177/20514158211016646 ◽

2021 ◽

pp. 205141582110166

Author(s):

Rico Luis ◽

Villasante Nicolás ◽

Blas Leandro ◽

Bonnano Nicolás ◽

Ameri Carlos

Keyword(s):

Sexual Function ◽

Tunica Albuginea ◽

Peyronie’S Disease ◽

Sexual Life ◽

Rank Test ◽

Penile Curvature ◽

Initial Experience ◽

Level Of Evidence ◽

Paired Samples ◽

Peyronie's Disease

Background: Peyronie’s disease (PD) is a progressive disorder of the connective tissue of the tunica albuginea of the penis that produces an abnormal curvature, painful erections and different degrees of erectile dysfunction (ED). The aim of this study is to evaluate our initial experience in the surgical treatment of PD using an autologous graft of testicular vaginal tunica. Materials and methods: A retrospective study of 23 patients was carried out between 2015 and 2019. The successful surgical stretching rate was defined as a functional 20 degrees of curvature or less. Postoperative sexual function and complications rate were evaluated as secondary objectives. We used the abbreviated IIEF-5 questionnaire and evaluated the sexual function before and after the surgical procedure. Wilcoxon signed-rank test for paired samples (U test) was used, considering a value of p<0.05 to be statistically significant. Results: Only one patient presented a recurrence of the penile curvature, resulting in a 95.6% success rate of functional stretching. We observed a 1.6 and 0.9 difference between pre- and postoperative total score and satisfaction ( p = 0.002 and p = 0.003 respectively) Conclusion: In this series, the use of testicular vaginal tunic was found to be safe and effective with a significant change in the quality of sexual life, especially reflected in the overall satisfaction after the procedure and a low rate of complications. Level of evidence: Not applicable for this multicentre audit.

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