Optimal Parameters for Eliciting Cardio-Acceleration by Electrical Stimulation of the Ventromedial Hypothalamus

1975 ◽  
Vol 94 (2) ◽  
pp. 189-197
Author(s):  
G. Johansson ◽  
R. Kalimo ◽  
T. Pääkkönen ◽  
S. Ruusunen
Keyword(s):  
Electrical Stimulation ◽  
Ventromedial Hypothalamus ◽  
Optimal Parameters ◽  
Stimulation Of

Hemodynamic effects of electrical stimulation of forebrain angiotensin and osmosensitive sites

1978 ◽  
Vol 235 (4) ◽  
pp. H445-H451 ◽  
Keyword(s):  
Blood Flow ◽  
Electrical Stimulation ◽  
Arterial Pressure ◽  
Median Eminence ◽  
Regional Blood Flow ◽  
Renal Hypertension ◽  
Brain Structures ◽  
Ventromedial Hypothalamus ◽  
Pressure Changes ◽  
Stimulation Of

Previous studies from this laboratory have indicated an important role for angiotensin-sensitive anteroventral third ventricular (AV3V) brain structures in normal regulation of arterial pressure and development of renal hypertension. The present experiments examined the effects of electrical stimulation of these periventricular areas on arterial pressure and regional blood flow in the anesthetized rat. Electrodes were placed in the AV3V region 3–10 days prior to acute studies. Blood flow was measured in extracorporeal blood flow circuits. Electrical stimulation produced only small changes in arterial pressure. Despite the small pressure changes, stimulation caused marked frequency-dependent alterations in regional blood flow. Renal and splanchnic flows were reduced while hindlimb flow was increased. Resistance changes were abolished by surgical denervation or ganglionic blockade but were unaffected by adrenalectomy. Hemodynamic responses to AV3V stimulation were abolished by a lesion in the area of the median eminence. It may be concluded that AV3V stimulation, through activation of pathways descending through the ventromedial hypothalamus-median eminence region, produces profound regional blood flow shifts without greatly altering arterial pressure.

scholarly journals Programming a Cochlear Implant for Tinnitus Suppression

2020 ◽  
Vol 31 (04) ◽  
pp. 302-308 ◽  
Author(s):  
Ann Perreau ◽  
Richard Tyler ◽  
Patricia C. Mancini
Keyword(s):  
Electrical Stimulation ◽  
Cochlear Implant ◽  
Clinical Research ◽  
Clinical Setting ◽  
Optimal Parameters ◽  
Research Designs ◽  
Optimal Programming ◽  
Stimulation Of ◽  
Research Studies

Abstract Background Electrical stimulation of the cochlea to treat tinnitus has been explored for decades. However, few studies have investigated the most salient programming parameters for tinnitus suppression in cochlear implant (CI) patients. Purpose The purpose of this study was to review the available CI programming parameters for tinnitus suppression and to consider possible clinical research designs for selecting the optimal programming parameters for CI patients. Results Across research studies, the optimal parameters vary significantly and are often based on data fromonly a fewparticipants. Electrical stimulation using lowand high rates, different electrode numbers, and low T-levels were helpful in suppressing tinnitus, although more research is needed from a greater number of CI patients. Possible designs for evaluating these parameters in a clinical setting are presented. Conclusions Programming a CI to reduce the prominence of tinnitus is complex, and audiologists should consider adjusting CI parameters systematically for CI patients with bothersome tinnitus.

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