A Common Binding Site for Channel-Permeant Cations and Local Anesthetics on the Nicotinic Acetylcholine Receptor

Local Anesthetics ◽

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54504-x ◽

1991 ◽

Vol 266 (34) ◽

pp. 23354-23364

Author(s):

J.B. Cohen ◽

S.D. Sharp ◽

W.S. Liu

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Cation Binding ◽

Agonist Binding ◽

Expression of the alpha-bungarotoxin binding site of the nicotinic acetylcholine receptor by Escherichia coli transformants.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.12.4318 ◽

1987 ◽

Vol 84 (12) ◽

pp. 4318-4321 ◽

Cited By ~ 44

Author(s):

J. M. Gershoni

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin

Probing the Agonist Domain of the Nicotinic Acetylcholine Receptor by Cysteine Scanning Mutagenesis Reveals Residues in Proximity to the α-Bungarotoxin Binding Site†

Biochemistry ◽

10.1021/bi982656z ◽

1999 ◽

Vol 38 (16) ◽

pp. 4912-4921 ◽

Cited By ~ 18

Author(s):

Armin Spura ◽

Tanya S. Russin ◽

Neal D. Freedman ◽

Marianne Grant ◽

James T. McLaughlin ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Journal of Biological Chemistry ◽

10.1074/jbc.m117.815316 ◽

2017 ◽

Vol 293 (7) ◽

pp. 2534-2545 ◽

Cited By ~ 15

Author(s):

Florian Delbart ◽

Marijke Brams ◽

Fabian Gruss ◽

Sam Noppen ◽

Steve Peigneur ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Binding Protein ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein

A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.708 ◽

2010 ◽

Vol 98 (3) ◽

pp. 131a

Author(s):

Ayman K. Hamouda ◽

Deidre Stewart ◽

S. Shaukat Husain ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface ◽

A Subunit

Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism

Journal of Agricultural and Food Chemistry ◽

10.1021/jf4030695 ◽

2013 ◽

Vol 61 (33) ◽

pp. 7883-7888 ◽

Cited By ~ 38

Author(s):

Xusheng Shao ◽

Tami L. Swenson ◽

John E. Casida

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Receptor Binding ◽

Receptor Binding Site ◽

3P-085 Molecular recognition of barbiturate enantiomer in agonist binding site of nicotinic acetylcholine receptor(The 46th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri ◽

10.2142/biophys.48.s140_4 ◽

2008 ◽

Vol 48 (supplement) ◽

pp. S140

Author(s):

Masayuki Ozaki ◽

Tomoyoshi Seto

Keyword(s):

Molecular Recognition ◽

Binding Site ◽

Annual Meeting ◽

Acetylcholine Receptor ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Biophysical Society

Imidacloprid Binding Site in Musca Nicotinic Acetylcholine Receptor: Interactions with Physostigmine and a Variety of Nicotinic Agonists with Chloropyridyl and Chlorothiazolyl Substituents

Pesticide Biochemistry and Physiology ◽

10.1006/pest.1995.1042 ◽

1995 ◽

Vol 52 (3) ◽

pp. 170-181 ◽

Cited By ~ 27

Author(s):

M.Y. Liu ◽

B. Latli ◽

J.E. Casida

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Nicotinic Agonists ◽

Receptor Interactions

Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor

Journal of Biological Chemistry ◽

10.1074/jbc.275.17.12651 ◽

2000 ◽

Vol 275 (17) ◽

pp. 12651-12660 ◽

Cited By ~ 37

Author(s):

Deirdre A. Sullivan ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Agonist Binding ◽

Monoclonal antibodies directed against the neurotransmitter binding site of nicotinic acetylcholine receptor

FEBS Letters ◽

10.1016/0014-5793(80)81066-0 ◽

1980 ◽

Vol 120 (1) ◽

pp. 145-148 ◽

Cited By ~ 60

Author(s):

Richard W. James ◽

Ann C. Kato ◽

Marie-Joseph Rey ◽

Bernard W. Fulpius

Keyword(s):

Monoclonal Antibodies ◽

Binding Site ◽

Acetylcholine Receptor ◽