Inter-Species Chimeras of Leukemia Inhibitory Factor Define a Human Receptor Binding Sitea

2006 ◽  
Vol 762 (1) ◽  
pp. 165-178 ◽  
Author(s):  
CATHERINE M. OWCZAREK ◽  
MEREDITH J. LAYTON ◽  
DONALD METCALF ◽  
ROSLYN CLARK ◽  
NICHOLAS M. GOUGH ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Human Receptor

scholarly journals Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant.

1993 ◽  
Vol 12 (9) ◽  
pp. 3487-3495 ◽  
Author(s):  
C.M. Owczarek ◽  
M.J. Layton ◽  
D. Metcalf ◽  
P. Lock ◽  
T.A. Willson ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Human Receptor

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity and Pathogenesis?

2020 ◽  
Author(s):  
Angelo Spinello ◽  
Andrea Saltalamacchia ◽  
Alessandra Magistrato
Keyword(s):  
Health Economic ◽  
Global Health ◽  
Receptor Binding ◽  
Binding Motif ◽  
Spike Glycoprotein ◽  
High Affinity ◽  
Global Pandemic ◽  
Medical Countermeasures ◽  
High Infectivity ◽  
Human Receptor

<p>The latest outbreak of a new pathogenic coronavirus (SARS-CoV-2) is provoking a global health, economic and societal crisis. All-atom simulations enabled us to uncover the key molecular traits underlying the high affinity of SARS-CoV-2 spike glycoprotein towards its human receptor, providing a rationale to its high infectivity. Harnessing this knowledge can boost developing effective medical countermeasures to fight the current global pandemic.</p>

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