Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta-analysis

2012 ◽  
Vol 7 (1) ◽  
pp. 74-90 ◽  
Author(s):  
Danlei Yang ◽  
Hao Luo ◽  
Jianmiao Wang ◽  
Hansvin Bunjhoo ◽  
Yongjian Xu ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Meta Analysis ◽  
Receptor Antagonists ◽  
Moderate Asthma ◽  
Leukotriene Receptor Antagonists ◽  
Adolescents And Adults ◽  
Leukotriene Receptor

Treatment and Prevention of Periprosthetic Capsular Contracture in Breast Surgery With Prosthesis Using Leukotriene Receptor Antagonists: A Meta-Analysis

2021 ◽  
Author(s):  
Andrei Pașca ◽  
Eduard-Alexandru Bonci ◽  
Codruța Chiuzan ◽  
Nicoleta Monica Jiboc ◽  
Vlad Alexandru Gâta ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Breast Surgery ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Capsular Contracture ◽  
Risk Difference ◽  
Receptor Antagonists ◽  
Leukotriene Receptor Antagonists ◽  
Treatment And Prevention ◽  
Leukotriene Receptor

Abstract Background Capsular Contracture (CC) is the most common long-term complication of breast surgery with prosthesis. Leukotriene Receptor Antagonists (LRAs) have been tested as a potential treatment; however, mixed results have been observed. Objectives This study presents a meta-analysis to clarify the treatment and prophylactic capabilities of LRAs in the management of CC. Methods A systematic literature search in the most popular English databases was performed to identify relevant primary publications. We included all studies that evaluated the treatment and preventive capabilities of LRAs using the Baker scale assessment. Results Six eligible studies were included based on predefined inclusion and exclusion criteria, totalling 2276 breasts, out of which 775 did not receive LRAs and 1501 did. Final pooled results showed that LRAs could help manage CC with a Risk Difference (RD) of -0.38 with the corresponding 95% Confidence Interval (CI) between -0.69 and -0.08, showing statistical significance at a Z value of 2.48, p=0.01. Subgroup analysis based on the type of drug used showed that only montelukast yielded statistical significance (RD=-0.27, 95% CI between -0.51 and -0.03, Z=2.20, p=0.03). Zafirlukast did not seem to influence CC. Further subgroup analysis based on treatment timing showed that prophylaxis was ineffective and only treatment for ongoing CC yielded statistical significance. Conclusions The current meta-analysis proved that LRAs could be used in the management of CC. Only treatment for the ongoing CC showed statistical significance. Montelukast seemed to be more efficient with a safer profile for adverse effects, while zafirlukast yielded no statistical significance.

Treatment Persistence with Leukotriene Receptor Antagonists and Inhaled Corticosteroids

2005 ◽  
Vol 42 (5) ◽  
pp. 385-393 ◽  
Author(s):  
Marc Dorais ◽  
Lucie Blais ◽  
Isabelle Chabot ◽  
Jacques LeLorier
Keyword(s):  
Inhaled Corticosteroids ◽  
Receptor Antagonists ◽  
Treatment Persistence ◽  
Leukotriene Receptor Antagonists ◽  
Leukotriene Receptor

scholarly journals Introduction of Leukotriene Receptor Antagonists in Manitoba

2006 ◽  
Vol 13 (2) ◽  
pp. 94-98 ◽  
Author(s):  
C Macie ◽  
K Wooldrage ◽  
J Manfreda ◽  
NR Anthonisen
Keyword(s):  
Inhaled Corticosteroids ◽  
Patient Characteristics ◽  
Prescribing Patterns ◽  
Chronic Obstructive ◽  
Receptor Antagonists ◽  
Obstructive Pulmonary Disease ◽  
Physician Visits ◽  
Leukotriene Receptor Antagonists ◽  
Leukotriene Receptor ◽  
Health Database

Patient characteristics and prescribing patterns during the introduction of leukotriene receptor antagonists (LTRA) in Manitoba are described using the provincial health database. Residents of Manitoba with asthma, chronic obstructive pulmonary disease, bronchitis or claims for respiratory medications were identified. Six thousand forty-one of 160,626 (3.8%) patients received LTRA; the likelihood of receiving LTRA increased if a patient was younger than 15 years, lived in a rural locale, had asthma, had frequent physician visits or used inhaled corticosteroids. Subsequent prescriptions (68%) were associated with the number of physician visits and inhaled corticosteroid use, which were thought to be indexes of severity. Patients, especially children, who received more than five prescriptions showed evidence of increased asthma control, but there was little evidence of benefit in less selected patient groups due, at least in part, to poor compliance with all respiratory drugs.

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