EFFECTS OF DENERVATIONS ON THE ACETYLCHOLINESTERASE-CONTAINING AND FLUORESCENT NERVES OF THE RAT IRIS

2009 ◽  
Vol 54 (1) ◽  
pp. 85-98 ◽  
Author(s):  
ANTERO HUHTALA ◽  
TIMO TERVO ◽  
KAUKO T. HUIKURI ◽  
ARTO PALKAMA
Keyword(s):  
Rat Iris

Amitriptyline and imipramine inhibit the release of acetylcholine from parasympathetic nerve terminals in the rat iris

1984 ◽  
Vol 62 (7) ◽  
pp. 857-859 ◽  
Author(s):  
J. S. Richardson ◽  
T. G. Mattio ◽  
E. Giacobini
Keyword(s):  
Nerve Terminals ◽  
Dependent Manner ◽  
Parasympathetic Nerve ◽  
Drug Concentrations ◽  
Release Of Acetylcholine ◽  
Rat Iris ◽  
Anticholinergic Side Effects ◽  
Dose Dependent ◽  
Drug Free

The electrically stimulated release of [3H]acetylcholine from the parasympathetic nerve terminals of the rat iris in vitro is increased in a dose-dependent manner by scopolamine but is decreased by the tricyclic antidepressants amitriptyline and imipramine. The increased release in the presence of scopolamine seems to be due to the blockade of a presynaptic muscarinic autoreceptor that, in the drug-free state, inhibits the release of acetylcholine. However, at drug concentrations that should have comparable antimuscarinic potency, the antidepressants inhibit the release of acetylcholine. This suggests that the anticholinergic side effects of the antidepressants may be due to the reduced release of acetylcholine from parasympathetic nerve terminals as well as a possible direct postsynaptic muscarinic receptor blocking action. Whatever the mechanism of this action, the antidepressants do not have the same effect as scopolamine at the presynaptic muscarinic autoreceptor in the rat iris.

Substance P immunoreactive sensory nerves supply the rat iris and cornea

1981 ◽  
Vol 23 (3) ◽  
pp. 243-249 ◽  
Author(s):  
A. Miller ◽  
M. Costa ◽  
J.B. Furness ◽  
I.W. Chubb
Keyword(s):  
Substance P ◽  
Sensory Nerves ◽  
Rat Iris

scholarly journals Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

2017 ◽  
Vol 9 ◽  
pp. 1-11 ◽  
Author(s):  
Laura Garcia-Garcia ◽  
Sergio Recalde ◽  
Maria Hernandez ◽  
Jaione Bezunartea ◽  
Juan Roberto Rodriguez-Madoz ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Epithelial Cells ◽  
Sleeping Beauty ◽  
Sleeping Beauty Transposon ◽  
Rat Iris

Ultrastructural and histochemical studies of the rat iris: identified neuronal inputs and supportive glia

1984 ◽  
Vol 13 (5) ◽  
pp. 703-725 ◽  
Author(s):  
Kjell-Olof Hedlund ◽  
Christiane Ayer-Lelievre ◽  
H�kan Bj�rklund ◽  
Lena Hultgren ◽  
�ke Seiger
Keyword(s):  
Rat Iris

scholarly journals Effects of AF64A and pertussis toxin in the rat iris dilator.

1993 ◽  
Vol 61 ◽  
pp. 314
Author(s):  
Natsuki Suzuki ◽  
Yuji Imaizumi ◽  
Minoru Watanabe
Keyword(s):  
Pertussis Toxin ◽  
Rat Iris

scholarly journals Changes in Ca2+-sensitivity of the rat iris sphincter by AF64A.

1994 ◽  
Vol 64 ◽  
pp. 215
Author(s):  
Noriyuki Ikeno ◽  
Masako Tanaka ◽  
Natsuki Yamahara ◽  
Yoshiaki Uyama ◽  
Yuji Imaizumi ◽  
...  
Keyword(s):  
Rat Iris ◽  
Iris Sphincter
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