The action of the local anaesthetic, benzyl alcohol and the monoamine oxidase inhibitor, clorgyline on the β-hydroxybutyrate dehydrogenase activity of adult and weanling rat brain mitochondria

1978 ◽  
Vol 30 (1) ◽  
pp. 711-714 ◽  
Author(s):  
Miles D. Houslay ◽  
Robert W. Palmer ◽  
R. Julian S. Duncan
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Benzyl Alcohol ◽  
Dehydrogenase Activity ◽  
Local Anaesthetic ◽  
Monoamine Oxidase Inhibitor ◽  
Brain Mitochondria ◽  
Oxidase Inhibitor ◽  
Rat Brain Mitochondria

scholarly journals Effect of phenylpyruvate on pyruvate dehydrogenase activity in rat brain mitochondria

1973 ◽  
Vol 134 (2) ◽  
pp. 539-544 ◽  
Author(s):  
John M. Land ◽  
John B. Clark
Keyword(s):  
Rat Brain ◽  
Dehydrogenase Activity ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Competitive Inhibitor ◽  
Brain Mitochondria ◽  
Significant Inhibition ◽  
Complex Activity ◽  
Rat Brain Mitochondria ◽  
Dehydrogenase Complex

1. The effects of phenylpyruvate, a metabolite produced in phenylketonuria, on the pyruvate dehydrogenase-complex activity were investigated in rat brain mitochondria. 2. Pyruvate dehydrogenase activity was measured by two methods, one measuring the release of 14CO2 from [1-14C]pyruvate and the other measuring the acetyl-CoA formed by means of the coupling enzyme, pigeon liver arylamine acetyltransferase (EC 2.3.1.5). In neither case was there significant inhibition of the pyruvate dehydrogenase complex by phenylpyruvate at concentrations below 2mm. 3. However, phenylpyruvate acted as a classical competitive inhibitor of the coupling enzyme arylamine acetyltransferase, with a Ki of 100μm. 4. It was concluded that the inhibition of pyruvate dehydrogenase by phenylpyruvate is unlikely to be a primary enzyme defect in phenylketonuria.

Stress causes an increase in endogenous monoamine oxidase inhibitor (tribulin) in rat brain

1988 ◽  
Vol 92 (2) ◽  
pp. 218-221 ◽  
Author(s):  
S.K. Bhattacharya ◽  
Vivette Glover ◽  
I. McIntyre ◽  
G. Oxenkrug ◽  
M. Sandler
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Pyruvate Dehydrogenase Activity in Osmotically Shocked Rat Brain Mitochondria: Stimulation by Oxaloacetate

1988 ◽  
Vol 50 (3) ◽  
pp. 673-680 ◽  
Author(s):  
Richard H. Haas ◽  
Geoffrey Thompson ◽  
Bernard Morris ◽  
Kelly Conright ◽  
Torre Andrews
Keyword(s):  
Rat Brain ◽  
Dehydrogenase Activity ◽  
Pyruvate Dehydrogenase ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria

Effects of chronic monoamine oxidase inhibitor treatment on biogenic amine metabolism in rat brain

1979 ◽  
Vol 18 (10) ◽  
pp. 771-776 ◽  
Author(s):  
D.S. Robinson ◽  
I.C. Campbell ◽  
Margaret Walker ◽  
Nancy J. Statham ◽  
W. Lovenberg ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Biogenic Amine ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Amine Metabolism ◽  
Inhibitor Treatment

scholarly journals Monoamine Oxidase-B Mediates Ecstasy-Induced Neurotoxic Effects to Adolescent Rat Brain Mitochondria

2007 ◽  
Vol 27 (38) ◽  
pp. 10203-10210 ◽  
Author(s):  
E. Alves ◽  
T. Summavielle ◽  
C. J. Alves ◽  
J. Gomes-da-Silva ◽  
J. C. Barata ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Monoamine Oxidase B ◽  
Rat Brain Mitochondria ◽  
Neurotoxic Effects
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