Hydrogen peroxide production by monoamine oxidase in isolated rat-brain mitochondria: its effect on glutathione levels and Ca2+ efflux

1990 ◽  
Vol 1035 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Gabriella Sandri ◽  
Enrico Panfili ◽  
Lars Ernster
Keyword(s):  
Hydrogen Peroxide ◽  
Monoamine Oxidase ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Hydrogen Peroxide Production ◽  
Rat Brain Mitochondria ◽  
Isolated Rat

Respiratory Activity of Isolated Rat Brain Mitochondria following in vitro Exposure to Oxygen Radicals

1983 ◽  
Vol 3 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Lars Hillered ◽  
Lars Ernster
Keyword(s):  
Xanthine Oxidase ◽  
Rat Brain ◽  
Oxygen Radicals ◽  
Respiratory Activity ◽  
Brain Mitochondria ◽  
Iron Chelate ◽  
Rat Brain Mitochondria ◽  
In Vitro Exposure ◽  
Isolated Rat

Respiratory activity of isolated rat brain mitochondria was measured following in vitro exposure to oxygen radicals. The radicals were generated by hypoxanthine and xanthine oxidase in the presence of a suitable iron chelate and caused a severe inhibition of respiration stimulated by phosphate plus ADP (with malate + glutamate as substrate). The damage could be prevented by catalase or high concentrations of mannitol, but not by superoxide dismutase. A similar effect was observed when hypoxanthine and xanthine oxidase were replaced by glucose and glucose oxidase or by hydrogen peroxide. Most of the findings indicate that the hydroxyl radical is the damaging agent. It is concluded that brain mitochondria exposed to oxygen radicals in vitro show an inhibition of respiratory activity similar to that reported by other investigators as occurring in mitochondria in vivo following transient cerebral ischemia. Therefore, oxygen radicals may contribute to this type of cell damage.

Low glucocorticoid concentrations decrease oxidative phosphorylation of isolated rat brain mitochondria: an additional effect of dexamethasone

2000 ◽  
Vol 14 (5) ◽  
pp. 493-500 ◽  
Author(s):  
Christophe Morin ◽  
Roland Zini ◽  
Nicolas Simon ◽  
Peggy Charbonnier ◽  
Jean-Paul Tillement ◽  
...  
Keyword(s):  
Oxidative Phosphorylation ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria ◽  
Isolated Rat

Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria

Metallomics ◽  
2013 ◽  
Vol 5 (6) ◽  
pp. 736 ◽  
Author(s):  
Fatemeh Shaki ◽  
Mir-Jamal Hosseini ◽  
Mahmoud Ghazi-Khansari ◽  
Jalal Pourahmad
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Energy Homeostasis ◽  
Brain Mitochondria ◽  
Depleted Uranium ◽  
Rat Brain Mitochondria ◽  
And Oxidative Stress ◽  
Isolated Rat

scholarly journals Monoamine Oxidase-B Mediates Ecstasy-Induced Neurotoxic Effects to Adolescent Rat Brain Mitochondria

2007 ◽  
Vol 27 (38) ◽  
pp. 10203-10210 ◽  
Author(s):  
E. Alves ◽  
T. Summavielle ◽  
C. J. Alves ◽  
J. Gomes-da-Silva ◽  
J. C. Barata ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Monoamine Oxidase B ◽  
Rat Brain Mitochondria ◽  
Neurotoxic Effects
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