Possible role of prostaglandins in post-tetanic potentiation at the nerve-muscle junction in the longitudinal muscle strip of guinea-pig ileum1

1984 ◽  
Vol 36 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Ondřej Kadlec ◽  
Karel Mašek ◽  
Vladimir Růžička ◽  
Isidor Šeferna
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Muscle Strip ◽  
Post Tetanic Potentiation ◽  
Nerve Muscle

The analysis of post-tetanic potentiation in guinea-pig ileum longitudinal muscle strip

1982 ◽  
Vol 79 (3-4) ◽  
pp. 245-255 ◽  
Author(s):  
Ondřej Kadlec ◽  
Isidor Šeferna ◽  
Karel Mašek ◽  
George T. Somogyi ◽  
Joseph Knoll
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Muscle Strip ◽  
Guinea Pig Ileum ◽  
Post Tetanic Potentiation

Investigations into the mechanism of morphine and ethanol inhibition in the guinea pig ileum longitudinal muscle strip

1980 ◽  
Vol 58 (3) ◽  
pp. 265-270 ◽  
Author(s):  
John G. Clement
Keyword(s):  
Guinea Pig ◽  
Muscarinic Receptors ◽  
Longitudinal Muscle ◽  
Opiate Receptor ◽  
Muscle Strip ◽  
Ethanol Inhibition ◽  
Twitch Response ◽  
Mechanism Of Inhibition ◽  
Ethanol Ethanol ◽  
A Site

It has been noted that the analgesic property of ethanol bears a marked resemblance to that of morphine. The purpose of this study was to determine if the mechanism of action of morphine and ethanol was similar using the guinea pig ileal longitudinal muscle strip (GPI-LMS). Ethanol (35–260 mM) depressed the twitch response and the acetylcholine- (ACh-), KCl-, and BaCl2-induced contractions to the same extent while having no significant effect on the binding of [3H]quinuclidinyl benzilate ([3H]QNB) to muscarinic receptors. Morphine (53–530 nM) inhibited the twitch response and to a lesser extent BaCl2- and KCl-induced contractions while having no significant effect on either ACh-induced contractions or the binding of [3H]QNB to muscarinic receptors. Naloxone and increased [Ca2+] reversed the inhibitory effects of morphine but not ethanol. Ethanol appears to inhibit a site after interaction of ACh with the receptor. Mechanism of inhibition of BaCl2 response is also different as naloxone and increased [Ca2+] reverse morphine but not ethanol inhibition. Ethanol inhibition in GPI-LMS does not involve the opiate receptor.

Effect of ascorbate on the contractile response induced by DMPP in guinea-pig ileal longitudinal muscle strip

1983 ◽  
Vol 89 (3-4) ◽  
pp. 229-234 ◽  
Author(s):  
Eiichi Hayashi ◽  
Kazumasa Shinozuka ◽  
Toshio Maeda ◽  
Mitsuhiro Takeda
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Contractile Response ◽  
Muscle Strip
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