A network meta-analysis of the relative efficacy of treatments for actinic keratosis of the face or scalp in Europe

2015 ◽  
Vol 30 (9) ◽  
pp. 1619-1620 ◽  
Author(s):  
R.M. Szeimies
Keyword(s):  
Actinic Keratosis ◽  
Meta Analysis ◽  
Relative Efficacy ◽  
The Face

Evaluation of the Effectiveness of Imiquimod and 5-Fluorouracil for the Treatment of Actinic Keratosis: Critical Review and Meta-Analysis of Efficacy Studies

2005 ◽  
Vol 9 (5) ◽  
pp. 209-214 ◽  
Author(s):  
Aditya K. Gupta ◽  
Valerie Davey ◽  
Heather McPhail
Keyword(s):  
Actinic Keratosis ◽  
Meta Analysis ◽  
Topical Therapy ◽  
Efficacy Rate ◽  
Invasive Squamous Cell Carcinoma ◽  
Primary Efficacy Variable ◽  
Treatment Area ◽  
Exposed Skin ◽  
The Face ◽  
Health Canada

Background: Actinic keratosis lesions occur frequently on sun-exposed skin of Caucasians. They become more prevalent with advancing age and are important in identifying the risk factor of those people possibly predisposed to invasive squamous cell carcinoma. Topical therapies are useful alternatives to cryotherapy for treating diffuse actinic damage and a number of preparations have been developed for treating actinic keratosis. Objectives: A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp. Methods: We searched MEDLINE (1966 to October 2004) for relevant studies evaluating the efficacy of actinic keratosis topical agents imiquimod and 5-fluorouracil (0.5%, 1%, and 5%). Studies included in this meta-analysis required a dosage regimen that was not significantly different from that approved by Health Canada and the U.S. FDA. Studies also required a well-defined treatment duration and followup period, with the primary efficacy variable being the complete (100%) clearance of all actinic keratosis lesions defined as the proportion of patients at followup with no clinically visible lesions in the treatment area. To determine the average efficacy rate for both drugs, the data from each study were combined for that drug. Results: Ten studies were included in the analysis. The average efficacy rate for each drug (with 95% confidence interval) was 5-fluorouracil, 52 ± 18% ( n = 6 studies, 145 subjects) and imiquimod, 70 ± 12% ( n = 4 studies, 393 subjects). Conclusions: The results of this meta-analysis show that both imiquimod and 5-fluorouracil are effective methods for the treatment of actinic keratosis and provide a useful alternative to cryotherapy. However, this analysis suggests that imiquimod may have higher efficacy than 5-fluorouracil for actinic keratosis lesions located on the face and scalp and therefore provides another option to dermatologists.

Relative Efficacy of Probiotics Compared with Standard Therapy for Diarrhea Treatment in Children Under Five Years of Age: A Meta-Analysis Evidence from Developing Countries

2020 ◽  
Author(s):  
Nurul Aini Suria Saputri ◽  
◽  
Tri Nugraha Susilawati ◽  
Vitri Widyaningsih ◽  
◽  
...  
Keyword(s):  
Developing Countries ◽  
Acute Diarrhea ◽  
Standard Therapy ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Gastrointestinal Diseases ◽  
Relative Efficacy ◽  
Children Under Five ◽  
Under Five ◽  
Review Manager

ABSTRACT Background: Probiotics have been widely studied in a variety of gastrointestinal diseases. There is high-quality evidence that probiotics are effective for acute infectious diarrhea. This study aimed to examine the relative efficacy of probiotics compared with standard therapy for diarrhea treatment in children under five using meta-analysis. Subjects and Method: A meta-analysis was carried out using systematic PRISMA guidelines. The review process begins with searching for articles published between 2009 and 2019 from PubMed, Clinical Key, ScienceDirect, and Scopus databases. This study obtained four articles that meet the criteria of the randomized controlled trial (RCT), the study subjects were toddlers and conducted in developing countries. A sample of 995 children was divided into two groups, 518 children received probiotics (intervention) and 477 children received standard therapy (control). The data were analyzed by Review Manager (RevMan) software 5.3 to assess Standardized Mean Difference (SMD). Results: Probiotics administration reduced duration of acute diarrhea in children under five than standard therapy, with pooled estimate= 0.30 (SMD= -0.30; 95% CI= – 0.56 to -0.03). Conclusion: Probiotics administration combined with standard therapy is effective to reduce the duration of acute diarrhea in children under five in developing countries. Keywords: acute diarrhea, probiotic, children under five Correspondence:Nurul Aini Suria Saputri. Midwifery Department, School of Health Polytechnics, Tanjungpinang/ Masters Program in Public Health, Universitas Sebelas Maret. Jl. Arief Rahman Hakim No.1, Tanjungpinang, Riau Islands. Email: [email protected]. Mobile: +6285743401971. DOI: https://doi.org/10.26911/the7thicph.03.95

scholarly journals Debunking: A Meta-Analysis of the Psychological Efficacy of Messages Countering Misinformation

2017 ◽  
Vol 28 (11) ◽  
pp. 1531-1546 ◽  
Author(s):  
Man-pui Sally Chan ◽  
Christopher R. Jones ◽  
Kathleen Hall Jamieson ◽  
Dolores Albarracín
Keyword(s):  
Public Policy ◽  
Meta Analysis ◽  
Attitudes And Beliefs ◽  
Policy Goal ◽  
The Face

This meta-analysis investigated the factors underlying effective messages to counter attitudes and beliefs based on misinformation. Because misinformation can lead to poor decisions about consequential matters and is persistent and difficult to correct, debunking it is an important scientific and public-policy goal. This meta-analysis ( k = 52, N = 6,878) revealed large effects for presenting misinformation ( ds = 2.41–3.08), debunking ( ds = 1.14–1.33), and the persistence of misinformation in the face of debunking ( ds = 0.75–1.06). Persistence was stronger and the debunking effect was weaker when audiences generated reasons in support of the initial misinformation. A detailed debunking message correlated positively with the debunking effect. Surprisingly, however, a detailed debunking message also correlated positively with the misinformation-persistence effect.

Sign in / Sign up

Export Citation Format

Share Document