A new approach for efficient synthesis of phenyllactic acid from L-phenylalanine: Pathway design and cofactor engineering

2018 ◽  
Vol 42 (5) ◽  
pp. e12584 ◽  
Author(s):  
Xiuting Wang ◽  
Ying Hou ◽  
Long Liu ◽  
Jianghua Li ◽  
Guocheng Du ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Cofactor Engineering ◽  
Phenyllactic Acid ◽  
New Approach

A Simple and Efficient Synthesis of fused Benzo[b]thiophene Derivatives

Synthesis ◽  
2021 ◽  
Author(s):  
Alexander S. Fisyuk ◽  
Sergey A. Chernenko ◽  
Anastasia S. Kostyuchenko ◽  
Anna Samsonenko ◽  
Anton L. Shatsauskas ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Efficient Method ◽  
Oxidative Coupling ◽  
Pyridine Ring ◽  
Efficient Synthesis ◽  
New Approach ◽  
Fused Heterocycles ◽  
Palladium Catalyzed ◽  
Thiophene Derivatives

A new approach to the synthesis of fused benzothiophene derivatives was developed based on iodine-promoted photo-cyclization of 4,5-diarylsubstituted thiophenes obtained in three steps from commercially available compounds. Comparative analysis showed that photochemical cyclization is a more efficient method for the preparation of fused benzo[b]thiophene derivatives, compared to oxidative coupling 4,5-diarylsubstituted thiophenes in the presence of iron (III) chloride and palladium catalyzed intramolecular arylation. This approach provides an efficient synthesis of functionally substituted naphtho[2,1-b: 3,4-b ']dithiophenes, phenanthro[9,10-b] thiophenes, benzo[1,2-b: 3,4-b': 6 , 5-b '']trithiophenes, as well as new fused heterocycles containing a pyridine ring and / or a carbazole moiety

Copper-catalyzed substitution of allylic carbonates with diboron: A new approach to allylboronate synthesis

2008 ◽  
Vol 80 (5) ◽  
pp. 1039-1045 ◽  
Author(s):  
Hajime Ito ◽  
Shinichiro Ito ◽  
Yusuke Sasaki ◽  
Kou Matsuura ◽  
Masaya Sawamura
Keyword(s):  
Optically Active ◽  
New Method ◽  
Efficient Synthesis ◽  
Chirality Transfer ◽  
New Approach ◽  
Highly Efficient ◽  
Selective Substitution

Copper-catalyzed γ-selective substitution of allylic carbonates with diboron provides a new method for the efficient synthesis of allylboronates. Optically active α-chiral allylboronates were synthesized through the reaction of chiral allylic carbonates with bis(pinacolato)diboron in the presence of achiral Cu(I)-catalyst with highly efficient chirality transfer. Additionally, in the presence of a chiral Cu(I) catalyst, optically active α-chiral allylboronates were obtained with >90 % ee through the reaction of prochiral substrates with the diboron.

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