scholarly journals Precursors of ovarian cancer in the fallopian tube: Serous tubal intraepithelial carcinoma - an update

2014 ◽  
Vol 41 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Felix Zeppernick ◽  
Ivo Meinhold-Heerlein ◽  
Ie-Ming Shih
Keyword(s):  
Ovarian Cancer ◽  
Fallopian Tube ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Intraepithelial Carcinoma

scholarly journals Serous Tubal Intraepithelial Carcinoma or Not? Metastases to Fallopian Tube Mucosa Can Masquerade as In Situ Lesions

2017 ◽  
Vol 141 (10) ◽  
pp. 1313-1315 ◽  
Author(s):  
Reena Singh ◽  
Kathleen R. Cho
Keyword(s):  
Fallopian Tube ◽  
De Novo ◽  
Data Sources ◽  
High Grade ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Different Types ◽  
Intraepithelial Carcinoma ◽  
A Site ◽  
Immunohistochemical Stains

Context.— Nonuterine high-grade serous carcinomas (HGSCs) are believed to arise most often from precursors in the fallopian tube referred to as serous tubal intraepithelial carcinomas (STICs). A designation of tubal origin has been suggested for all cases of nonuterine HGSC if a STIC is identified. Objective.— To highlight that many different types of nongynecologic and gynecologic carcinomas, including HGSC, can metastasize to the tubal mucosa and mimic de novo STIC. Data Sources.— A mini-review of several recently published studies that collectively examine STIC-like lesions of the fallopian tube. Conclusions.— The fallopian tube mucosa can be a site of metastasis from carcinomas arising elsewhere, and pathologists should exercise caution in diagnosing STIC without first considering the possibility of metastasis. Routinely used immunohistochemical stains can often be used to determine if a STIC-like lesion is tubal or nongynecologic in origin. In the context of uterine and nonuterine HGSC, STIC may represent a metastasis rather than the site of origin, particularly when widespread disease is present.

scholarly journals Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Junzheng Yang ◽  
Yilan Zhou ◽  
Shu-Kay Ng ◽  
Kuan-Chun Huang ◽  
Xiaoyan Ni ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fallopian Tube ◽  
Intraepithelial Carcinoma

scholarly journals Cytomorphologic and molecular analyses of fallopian tube fimbrial brushings for diagnosis of serous tubal intraepithelial carcinoma

2019 ◽  
Vol 127 (3) ◽  
pp. 192-201
Author(s):  
M. Herman Chui ◽  
Russell Vang ◽  
Tian‐Li Wang ◽  
Ie‐Ming Shih ◽  
Christopher J. VandenBussche
Keyword(s):  
Fallopian Tube ◽  
Molecular Analyses ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Intraepithelial Carcinoma

Papillary Syncytial Metaplasia of Fallopian Tube Endometriosis: A Potential Pitfall in the Diagnosis of Serous Tubal Intraepithelial Carcinoma

2013 ◽  
Vol 137 (1) ◽  
pp. 126-129
Author(s):  
Harkiran Kaur ◽  
Elyse Levinsky ◽  
Terence J. Colgan
Keyword(s):  
Natural History ◽  
Fallopian Tube ◽  
Epithelial Proliferation ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Potential Pitfall ◽  
Significant Challenge ◽  
Histopathologic Diagnosis ◽  
Complete Study ◽  
Intraepithelial Carcinoma ◽  
Risk Reducing

Histopathologic diagnosis of tubal intraepithelial carcinoma (TIC) has emerged as a significant challenge in the last few years. The avoidance of pitfalls in the diagnosis of TIC is crucial if a better understanding of its natural history and outcome is to be achieved. Herein, we present a case of a 52-year-old woman who underwent a risk-reducing salpingo-oophorectomy procedure. Histologic examination of a fallopian tube demonstrated a focus of atypical epithelial proliferation, which was initially considered to be a TIC. Complete study of the case indicated that the focus was, in fact, papillary syncytial metaplasia of tubal mucosal endometriosis. Papillary syncytial metaplasia may resemble TIC and should be considered in cases of proliferative lesions of the tubal epithelium.

Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development

2016 ◽  
Vol 468 (6) ◽  
pp. 707-713 ◽  
Author(s):  
Karin Malmberg ◽  
Charlotta Klynning ◽  
Angelique Flöter-Rådestad ◽  
Joseph W. Carlson
Keyword(s):  
Fallopian Tube ◽  
Serous Carcinoma ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Intraepithelial Carcinoma

Ovarian Carcinosarcoma and Concurrent Serous Tubal Intraepithelial Carcinoma With Next-Generation Sequencing Suggesting an Origin From the Fallopian Tube

2019 ◽  
Vol 27 (5) ◽  
pp. 574-579 ◽  
Author(s):  
Sharlene Helene C. See ◽  
Amir Behdad ◽  
Kruti P. Maniar ◽  
Luis Z. Blanco
Keyword(s):  
Next Generation Sequencing ◽  
Fallopian Tube ◽  
Tp53 Gene ◽  
Serous Carcinoma ◽  
High Grade ◽  
Next Generation ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Divergent Differentiation ◽  
Intraepithelial Carcinoma ◽  
Generation Sequencing

Background. Ovarian carcinosarcomas are rare aggressive biphasic tumors. Evidence suggests that these tumors are monoclonal and that the sarcoma component is derived from a stem cell undergoing divergent differentiation. Currently, there remains a paucity of data regarding its origin, with few reports suggesting an association with serous tubal intraepithelial carcinoma (STIC) by immunohistochemistry and genetics. Objective. We sought to determine the relationship of carcinosarcoma to high-grade serous carcinoma and STIC by investigating for similar mutation signatures through next-generation sequencing. Methodology. A case of carcinosarcoma with associated high-grade serous carcinoma and STIC was macrodissected, and next-generation sequencing was performed on each component separately. Results. The STIC, high-grade serous carcinoma component, and chondrosarcoma component were all diffusely positive for p53 and p16 by immunohistochemistry. Next-generation sequencing demonstrated an identical TP53 gene c.376-1G>A 5’ splice site pathogenic mutation in all 3 components. Conclusions. Our findings suggest that carcinosarcomas may also originate from the fallopian tube.

scholarly journals Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma

2018 ◽  
Vol 28 (8) ◽  
pp. 1535-1544
Author(s):  
Zakia A. Abdelhamed ◽  
Thomas A. Ryan ◽  
Martin Fuller ◽  
Camilla Coulson-Gilmer ◽  
Dina I. Abdelmottaleb ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Sonic Hedgehog ◽  
Immunohistochemical Staining ◽  
Hedgehog Signaling ◽  
Primary Cilia ◽  
Secretory Cells ◽  
Sonic Hedgehog Signaling ◽  
Serous Tubal Intraepithelial Carcinoma ◽  
Intraepithelial Carcinoma ◽  
Motile Cilia

ObjectivesThe aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial carcinoma (STIC).MethodsFallopian tube tissue samples were obtained from 4 females undergoing prophylactic hysterectomies and 6 patients diagnosed with STIC. A mogp-TAg transgenic mouse STIC sample was also compared with a wild-type mouse FT sample. Serous tubal intraepithelial carcinoma was identified by hematoxylin and eosin staining and confirmed by positive Ki-67 and p53 immunohistochemical staining of tissue sections. We assessed the relative distribution of primary cilia on secretory cells and motile cilia on multiple ciliated cells by immunofluorescence and immunohistochemical staining. Ciliary function was assessed by immunofluorescence staining of specific ciliary marker proteins and responsiveness to Sonic Hedgehog signaling.ResultsPrimary cilia are widespread on secretory cells in the ampulla, isthmus, and in particular, the fimbriae of human FT where they may appear to mediate ciliary-mediated Sonic Hedgehog signaling. A statistically significant reduction in the number of primary cilia on secretory cells was observed in human STIC samples compared with normal controls (P < 0.0002, Student t test), supported by similar findings in a mouse STIC sample. Immunohistochemical staining for dynein axonemal heavy chain 5 discriminated multiple motile cilia from primary cilia in human FT.ConclusionsPrimary cilia are widespread on secretory cells in the ampulla, isthmus, and in particular, the fimbriae of the human FT but are significantly reduced in both human and mouse STIC samples. Immunohistochemical staining for ciliary proteins may have clinical utility for early detection of STIC.

Sign in / Sign up

Export Citation Format

Share Document