scholarly journals Randomized double-blind comparison of the effects of intramyometrial and intravenous oxytocin during elective cesarean section

2016 ◽  
Vol 42 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Chieko Akinaga ◽  
Sakiko Uchizaki ◽  
Tadayoshi Kurita ◽  
Mizuki Taniguchi ◽  
Hiroshi Makino ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Elective Cesarean Section ◽  
Double Blind ◽  
Elective Cesarean ◽  
Blind Comparison

scholarly journals Efficacy of Phenylephrine in Preventing Hemodynamic Responses of Oxytocin during Elective Cesarean Section: A Randomized, Double-Blind, Controlled Trial

2019 ◽  
Vol 55 (01) ◽  
pp. 048-053
Author(s):  
Medha Mohta ◽  
Vijay Kumar ◽  
Rachna Agarwal ◽  
Geetanjali T. Chilkoti ◽  
Sakshi Duggal
Keyword(s):  
Cesarean Section ◽  
Normal Saline ◽  
Controlled Trial ◽  
Saline Group ◽  
Elective Cesarean Section ◽  
Hemodynamic Changes ◽  
Singleton Pregnancy ◽  
Double Blind ◽  
Elective Cesarean ◽  
Better Than

AbstractThis study compared hemodynamic changes and occurrence of complications following oxytocin administration with a prior injection of phenylephrine 100 μg or normal saline during elective cesarean section. Sixty-six healthy term parturients with uncomplicated, singleton pregnancy undergoing elective cesarean section under spinal anesthesia were studied. They received either intravenous phenylephrine 100 μg or normal saline before oxytocin 3 IU was administered over 30 seconds. Oxytocin dose was repeated depending on the adequacy of uterine tone. There was no significant change in systolic, diastolic, and mean arterial pressures during the initial 3 minutes following oxytocin administration in the phenylephrine group but a significant fall in mean and diastolic pressures in the saline group. Heart rate did not change significantly, and no significant complications occurred in either of the groups. To conclude, phenylephrine 100 μg administered before oxytocin injection maintained hemodynamic parameters better than normal saline injection during elective cesarean section.

scholarly journals Comparison of Short Vs. Long Half-Life Single-Dose Prophylactic Antibiotics for Cesarean Section

1994 ◽  
Vol 2 (3) ◽  
pp. 120-125 ◽  
Author(s):  
Bernard Gonik ◽  
James McGregor
Keyword(s):  
Single Dose ◽  
Cesarean Section ◽  
Half Life ◽  
Study Groups ◽  
Elective Cesarean Section ◽  
Double Blind ◽  
Prophylactic Efficacy ◽  
Cord Clamping ◽  
Containment Measures ◽  
Elective Cesarean

Objective:Numerous studies demonstrate the efficacy of antibiotic prophylaxis for reducing postcesarean section infectious morbidity. The duration of therapy, however, remains controversial. Cost containment measures and the ease of single dosing have led to the introduction of “extended” half-life agents for cesarean-section chemoprophylaxis. We tested the hypothesis that there was no difference in efficacy between a single dose of a short half-life agent (cefoxitin) and a longer half-life agent (cefotetan).Methods:A prospective, double-blind trial of 375 non-elective cesarean-section cases was carried out. Study antibiotics (2 g) were administered intravenously (IV) at cord clamping only.Results:Demographic and clinical variables between the 2 study groups were similar. No significant differences were noted in major or minor morbidity or in infectious morbidities for patients receiving the 2 prophylactic regimens. The occurrence of postoperative endometritis was likewise similar for the subjects receiving cefoxitin (10%) and cefotetan (15%). When cases whose surgery lasted >60 min were evaluated separately, no differences in outcomes between the 2 groups were identifiedConclusions:These findings confirm our hypothesis that the half-life difference between these 2 agents does not impact on single-dose Prophylactic efficacy in cesarean section.

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