Distinct MR Imaging Features of Triple-Negative Breast Cancer with Brain Metastasis

2014 ◽  
Vol 25 (3) ◽  
pp. 474-481 ◽  
Author(s):  
Ren-Hua Yeh ◽  
Jyh-Cherng Yu ◽  
Chi-Hong Chu ◽  
Ching-Liang Ho ◽  
Hung-Wen Kao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Mr Imaging ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Imaging Features

Heterogeneity of triple-negative breast cancer: mammographic, US, and MR imaging features according to androgen receptor expression

2014 ◽  
Vol 25 (2) ◽  
pp. 419-427 ◽  
Author(s):  
Min Sun Bae ◽  
So Yeon Park ◽  
Sung Eun Song ◽  
Won Hwa Kim ◽  
Su Hyun Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Mr Imaging ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Imaging Features

Magnetic Resonance Imaging Features in Triple-Negative Breast Cancer: Comparison With Luminal and HER2-Overexpressing Tumors

2012 ◽  
Vol 12 (5) ◽  
pp. 331-339 ◽  
Author(s):  
Melania Costantini ◽  
Paolo Belli ◽  
Daniela Distefano ◽  
Enida Bufi ◽  
Marialuisa Di Matteo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Imaging Features ◽  
Resonance Imaging

scholarly journals MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer

Oncogene ◽  
2021 ◽  
Author(s):  
Jhih-Kai Pan ◽  
Cheng-Han Lin ◽  
Yao-Lung Kuo ◽  
Luo-Ping Ger ◽  
Hui-Chuan Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Survival Outcomes ◽  
Poor Survival ◽  
Breast Cancer Brain Metastasis ◽  
High Level

AbstractBrian metastasis, which is diagnosed in 30% of triple-negative breast cancer (TNBC) patients with metastasis, causes poor survival outcomes. Growing evidence has characterized miRNAs involving in breast cancer brain metastasis; however, currently, there is a lack of prognostic plasma-based indicator for brain metastasis. In this study, high level of miR-211 can act as brain metastatic prognostic marker in vivo. High miR-211 drives early and specific brain colonization through enhancing trans-blood–brain barrier (BBB) migration, BBB adherence, and stemness properties of tumor cells and causes poor survival in vivo. SOX11 and NGN2 are the downstream targets of miR-211 and negatively regulate miR-211-mediated TNBC brain metastasis in vitro and in vivo. Most importantly, high miR-211 is correlated with poor survival and brain metastasis in TNBC patients. Our findings suggest that miR-211 may be used as an indicator for TNBC brain metastasis.

scholarly journals Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer

2019 ◽  
Vol 20 (12) ◽  
pp. 3080 ◽  
Author(s):  
Fan Wu ◽  
Robert D. McCuaig ◽  
Christopher R. Sutton ◽  
Abel H. Y. Tan ◽  
Yoshni Jeelall ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Cancer Progression ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Lung Metastases ◽  
Her2 Positive ◽  
Pathway Gene ◽  
Dual Specificity ◽  
The Brain

DUSP6 is a dual-specificity phosphatase (DUSP) involved in breast cancer progression, recurrence, and metastasis. DUSP6 is predominantly cytoplasmic in HER2+ primary breast cancer cells, but the expression and subcellular localization of DUSPs, especially DUSP6, in HER2-positive circulating tumor cells (CTCs) is unknown. Here we used the DEPArray system to identify and isolate CTCs from metastatic triple negative breast cancer (TNBC) patients and performed single-cell NanoString analysis to quantify cancer pathway gene expression in HER2-positive and HER2-negative CTC populations. All TNBC patients contained HER2-positive CTCs. HER2-positive CTCs were associated with increased ERK1/ERK2 expression, which are direct DUSP6 targets. DUSP6 protein expression was predominantly nuclear in breast CTCs and the brain metastases but not pleura or lung metastases of TNBC patients. Therefore, nuclear DUSP6 may play a role in the association with cancer spreading in TNBC patients, including brain metastasis.

scholarly journals Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

2020 ◽  
Vol 13 (6) ◽  
pp. 100775
Author(s):  
Christopher Butler ◽  
Samuel Sprowls ◽  
Gabor Szalai ◽  
Tasneem Arsiwala ◽  
Pushkar Saralkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Brain Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Hypomethylating Agent ◽  
Keratin 18

DNA Methylation of the Keratin 18 Gene Regulates Brain Metastasis of Triple Negative Breast Cancer

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Tuoen Liu ◽  
William Kohler ◽  
Benjamin Wolff ◽  
Christopher Butler ◽  
Gabor Szalai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Brain Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Keratin 18

Triple-Negative Breast Cancer: Correlation between MR Imaging and Pathologic Findings

Radiology ◽  
2009 ◽  
Vol 250 (3) ◽  
pp. 638-647 ◽  
Author(s):  
Takayoshi Uematsu ◽  
Masako Kasami ◽  
Sachiko Yuen
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Pathologic Findings

scholarly journals Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis

2015 ◽  
Vol 32 (7) ◽  
pp. 717-727 ◽  
Author(s):  
DeeDee Smart ◽  
Alejandra Garcia-Glaessner ◽  
Diane Palmieri ◽  
Sarah J. Wong-Goodrich ◽  
Tamalee Kramp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Brain Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Brain Metastasis
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