Safety, Feasibility, and Efficacy of Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury Neurogenic Bladder: A Randomized Control Pilot Trial

2018 ◽  
Vol 22 (6) ◽  
pp. 716-722 ◽  
Author(s):  
Argyrios Stampas ◽  
Radha Korupolu ◽  
Liang Zhu ◽  
Christopher P. Smith ◽  
Kenneth Gustafson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Nerve Stimulation ◽  
Tibial Nerve ◽  
Pilot Trial ◽  
Acute Spinal Cord Injury ◽  
Tibial Nerve Stimulation ◽  
Cord Injury ◽  
Randomized Control

Effects of Bilateral Transcutaneous Tibial Nerve Stimulation on Detrusor Overactivity in Spinal Cord Injury

2018 ◽  
Vol 99 (10) ◽  
pp. e77
Author(s):  
Wasuwat Kitisomprayoonkul ◽  
Kornkamon Kamboonlert ◽  
Sirikwan Panyasriwanit ◽  
Natthiya Tantisiriwat
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Stimulation ◽  
Detrusor Overactivity ◽  
Tibial Nerve ◽  
Tibial Nerve Stimulation ◽  
Cord Injury

Zoledronic Acid Treatment After Acute Spinal Cord Injury: Results of a Randomized, Placebo‐Controlled Pilot Trial

PM&R ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 833-843 ◽  
Author(s):  
Thomas J. Schnitzer ◽  
Ki Kim ◽  
Julia Marks ◽  
Renita Yeasted ◽  
Narina Simonian ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Zoledronic Acid ◽  
Acid Treatment ◽  
Pilot Trial ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals TASCI—transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e039164 ◽  
Author(s):  
Veronika Birkhäuser ◽  
Martina D Liechti ◽  
Collene E Anderson ◽  
Lucas M Bachmann ◽  
Sarah Baumann ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Tibial Nerve ◽  
Ethics Committee ◽  
Neurogenic Detrusor Overactivity ◽  
Double Blind ◽  
Tibial Nerve Stimulation ◽  
Double Blind Clinical Trial ◽  
Cord Injury

IntroductionNeurogenic lower urinary tract dysfunction (NLUTD), including neurogenic detrusor overactivity (NDO) and detrusor sphincter dyssynergia, is one of the most frequent and devastating sequelae of spinal cord injury (SCI), as it can lead to urinary incontinence and secondary damage such as renal failure. Transcutaneous tibial nerve stimulation (TTNS) is a promising, non-invasive neuromodulatory intervention that may prevent the emergence of the C-fibre evoked bladder reflexes that are thought to cause NDO. This paper presents the protocol for TTNS in acute SCI (TASCI), which will evaluate the efficacy of TTNS in preventing NDO. Furthermore, TASCI will provide insight into the mechanisms underlying TTNS, and the course of NLUTD development after SCI.Methods and analysisTASCI is a nationwide, randomised, sham-controlled, double-blind clinical trial, conducted at all four SCI centres in Switzerland. The longitudinal design includes a baseline assessment period 5–39 days after acute SCI and follow-up assessments occurring 3, 6 and 12 months after SCI. A planned 114 participants will be randomised into verum or sham TTNS groups (1:1 ratio), stratified on study centre and lower extremity motor score. TTNS is performed for 30 min/day, 5 days/week, for 6–9 weeks starting within 40 days after SCI. The primary outcome is the occurrence of NDO jeopardising the upper urinary tract at 1 year after SCI, assessed by urodynamic investigation. Secondary outcome measures assess bladder and bowel function and symptoms, sexual function, neurological structure and function, functional independence, quality of life, as well as changes in biomarkers in the urine, blood, stool and bladder tissue. Safety of TTNS is the tertiary outcome.Ethics and disseminationTASCI is approved by the Swiss Ethics Committee for Northwest/Central Switzerland, the Swiss Ethics Committee Vaud and the Swiss Ethics Committee Zürich (#2019-00074). Findings will be disseminated through peer-reviewed publications.Trial registration numberNCT03965299.

Sign in / Sign up

Export Citation Format

Share Document