Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Plasma motilin concentrations were measured in dogs following duodenal acidification and alkalinization and gastric instillation of fat. Antral and duodenal motility were recorded concurrently using intraluminal manometry. Alkalinization of the duodenum produced an increase in antral and duodenal motility and a significant rise in plasma motilin. Alkaline infusions at 5 mL/min into the duodenum initiated phase III of a migrating motor complex both in the antrum and in the duodenum. Duodenal acid infusions produced no change in plasma motilin concentrations while inhibiting antral motility and stimulating duodenal motility for the duration of the infusion. Gastric instillation of 60 g fat produced a 25% increase above basal motilin levels at 50 min after instillation. Motilin levels monitored during spontaneous migrating motor complexes showed peak motilin levels occurring during maximal activity of the antral duodenal region in seven out of nine motor complexes examined but motilin peaks also occurred without migrating complexes being present in this area and, as well, complexes occurred when motilin was undetectable. These results taken together with our other studies in man confirm that a true species difference exists between man and dog in the hormonal motor response to duodenal alkalinization. Although a relationship appears to exist between the appearance of maximal migrating motor complex activity in the gastroduodenal area and plasma motilin concentrations in dogs as in humans, the motilin peaks are probably neither necessary nor sufficient to induce phase III activity.

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T1678 Relationship Between Migrating Motor Complex and Plasma Levels of Gastrointestinal Hormones in Man

Gastroenterology ◽

10.1016/s0016-5085(09)62558-0 ◽

2009 ◽

Vol 136 (5) ◽

pp. A-556 ◽

Cited By ~ 1

Author(s):

Emidio Scarpellini ◽

Rita Vos ◽

Inge Depoortere ◽

Betty De Smet ◽

Pieter Vanden Berghe ◽

...

Keyword(s):

Plasma Levels ◽

Gastrointestinal Hormones ◽

Migrating Motor Complex ◽

Motor Complex

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Motor patterns of small intestine determined by closely spaced extraluminal transducers and videofluoroscopy

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1987.253.3.g259 ◽

1987 ◽

Vol 253 (3) ◽

pp. G259-G267 ◽

Cited By ~ 14

Author(s):

H. J. Ehrlein ◽

M. Schemann ◽

M. L. Siegle

Keyword(s):

Small Intestine ◽

Retrograde Transport ◽

Migrating Motor Complex ◽

Phase Iii ◽

Motor Patterns ◽

Motor Complex ◽

Enterogastric Reflux ◽

Propagating Contractions ◽

Propagation Velocities

In the canine small intestine several simple (S) and complex (C) patterns of propulsive and nonpropulsive activities were found. The nonpropulsive activity consisted of 1) stationary individual contractions (S) and 2) stationary clusters of contractions (C). Patterns leading to aboral propulsion of luminal contents were 1) propagating contractions (S), 2) propagating power contractions (S), 3) phase III of the migrating motor complex (C), and 4) migrating clusters of contractions (C). The propagation velocities of the propulsive motor patterns differed markedly; they increased in the following order: phase III, migrating clustered contractions, propagating power contractions, propagating contractions. A retrograde transport of luminal contents was produced by two different activities: 1) retrograde propagating contractions (S) and 2) retrograde power contractions (S). They were accompanied with enterogastric reflux.

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