scholarly journals Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor TGR5 agonist, INT-777: role of submucosal neurons

2016 ◽  
Vol 28 (11) ◽  
pp. 1663-1676 ◽  
Author(s):  
H. Duboc ◽  
G. Tolstanova ◽  
P.-Q. Yuan ◽  
V. S. Wu ◽  
I. Kaji ◽  
...  
Keyword(s):  
Bile Acid ◽  
Colonic Mucosa ◽  
Male Rat ◽  
Acid Receptor ◽  
Epithelial Secretion ◽  
Bile Acid Receptor

scholarly journals OP016 Potential role of bile acid receptor FXR in microscopic colitis

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S10-S10
Author(s):  
C. Palmela ◽  
J. Torres ◽  
P. Gomes de Sena ◽  
M.P. Costa Santos ◽  
C. Gouveia ◽  
...  
Keyword(s):  
Bile Acid ◽  
Potential Role ◽  
Microscopic Colitis ◽  
Acid Receptor ◽  
Bile Acid Receptor

The expanding role of the bile acid receptor FXR in the small intestine

2006 ◽  
Vol 44 (6) ◽  
pp. 1213-1215 ◽  
Author(s):  
Bertrand Cariou ◽  
Bart Staels
Keyword(s):  
Small Intestine ◽  
Bile Acid ◽  
Acid Receptor ◽  
Bile Acid Receptor

Role of nuclear bile acid receptor, FXR, in determining ATP-binding casette (ABC) transporter expression and cholestatic liver injury in common bile duct-ligated mice

2003 ◽  
Vol 124 (4) ◽  
pp. A697-A698
Author(s):  
Martin Wagner ◽  
Peter Fickert ◽  
Gemot Zollner ◽  
Andrea Fuchsbichler ◽  
Dagmar Silbert ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Common Bile Duct ◽  
Abc Transporter ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Cholestatic Liver Injury ◽  
Transporter Expression

scholarly journals Mo1676 The Role of Bile Acid Receptor FXR Activation on NHE8 Expression Regulation

2014 ◽  
Vol 146 (5) ◽  
pp. S-633
Author(s):  
Hua Xu ◽  
Jing Li ◽  
Meena Ananthanarayanan ◽  
Fayez K. Ghishan
Keyword(s):  
Bile Acid ◽  
Expression Regulation ◽  
Acid Receptor ◽  
Bile Acid Receptor

scholarly journals Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice

2006 ◽  
Vol 191 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Takaharu Maruyama ◽  
Kenichi Tanaka ◽  
Jun Suzuki ◽  
Hiroyuki Miyoshi ◽  
Naomoto Harada ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Physiological Role ◽  
Wild Type ◽  
Fat Accumulation ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
The Impact ◽  
G Protein Coupled

G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) is a novel G protein-coupled receptor for bile acid. Tissue distribution and cell-type specificity of Gpbar1 mRNA suggest a potential role for the receptor in the endocrine system; however, the precise physiological role of Gpbar1 still remains to be elucidated. To investigate the role of Gpbar1 in vivo, the Gpbar1 gene was disrupted in mice. In homozygous mice, total bile acid pool size was significantly decreased by 21–25% compared with that of the wild-type mice, suggesting that Gpbar1 contributes to bile acid homeostasis. In order to assess the impact of Gpbar1 deficiency in bile acid homeostasis more precisely, Gpbar1 homozygous mice were fed a high-fat diet for 2 months. As a result, female Gpbar1 homozygous mice showed significant fat accumulation with body weight gain compared with that of the wild-type mice. These findings were also observed in heterozygous mice to the same extent. Although the precise mechanism for fat accumulation in female Gpbar1 homozygous mice remains to be addressed, these data indicate that Gpbar1 is a potential new player in energy homeostasis. Thus, Gpbar1-deficient mice are useful in elucidating new physiological roles for Gpbar1.

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
C Chinatalpati ◽  
C Wöhler ◽  
C Ehlting ◽  
J Bode ◽  
D Häussinger ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled

Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
K Deutschmann ◽  
M Reich ◽  
A Lang ◽  
R Piekorz ◽  
D Häussinger ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Receptor ◽  
Bile Acid Receptor

A Pan-Cancer Analysis of the Oncogenic Role of G Protein-Coupled Bile Acid Receptor 1(GPBAR1) in Human Tumors

2021 ◽  
Author(s):  
Zhiyuan Guan ◽  
Xiao Jin ◽  
Shengfu Liu ◽  
Zhong Wu ◽  
Ruijun Cong ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Human Tumors ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled ◽  
Pan Cancer
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