The fatal consequence of inappropriate therapy in a single VF zone primary prevention defibrillator

2021 ◽  
Author(s):  
Samuel Griffiths ◽  
Jonathan M Behar ◽  
Karen Lascelles ◽  
Tom Wong
Keyword(s):  
Primary Prevention ◽  
Inappropriate Therapy ◽  
Fatal Consequence

Abstract 14546: Left Ventricular Sphericity Index as a Predictor of Appropriate Implantable Cardioverter-defibrillator Therapy

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Rahul Myadam ◽  
Jason D'Souza ◽  
Kensey Gosch ◽  
Daniel Steinhaus
Keyword(s):  
Primary Prevention ◽  
Proportional Hazards ◽  
Wall Stress ◽  
Left Ventricular ◽  
Cox Proportional Hazards ◽  
P Value ◽  
Inappropriate Therapy ◽  
Sphericity Index ◽  
All Cause Mortality ◽  
Appropriate Therapy

Introduction: We assessed the hypothesis that markers of LV wall stress, such as LV sphericity index (SI), may predict appropriate therapy for ventricular arrhythmias (VA) in patients with primary prevention defibrillators, independent of LV ejection fraction. Methods: We performed a retrospective analysis of consecutive patients with new ICD or CRT-D placement for primary prevention at a single hospital from 01/01/2015 to 06/30/2018. TTE images were used for calculating LV SI, which was defined as the ratio of bi-plane LV end-diastolic volume to the volume of a hypothetical sphere with a diameter of LV end-diastolic length in apical 4-chamber view. Device interrogations were reviewed for appropriate therapy for VA and inappropriate therapy for non-VAs. Kaplan-Meier curves stratified by LV SI tertile were constructed, and Cox proportional hazards models were used to evaluate time to appropriate and inappropriate therapy, and all-cause mortality. Results: A total of 282 patients (ICD 154, CRT-D 128) were included. Baseline characteristics are described in the Table. We found a trend towards increased appropriate therapy as LV SI increased in the ICD but not the CRT-D group, but this was non-significant in both (ICD log-rank 0.63, p-value 0.73; CRT-D log-rank 0.07, p-value 0.96). There was no correlation between LV SI and time to all-cause mortality in the ICD (log-rank 0.53, p-value 0.76) or the CRT-D patients (log-rank 0.51, p-value 0.77). LV SI correlated significantly with time to inappropriate therapy in the ICD (log-rank 8.6, p-value 0.01), but not the CRT-D patients (log-rank 2.4, p-value 0.3). Conclusions: LV SI demonstrated a non-significant trend towards increased appropriate device therapy in the ICD but not the CRT-D group. LV SI predicted inappropriate therapy in the ICD but not the CRT-D group. Study power was limited by lower than expected event rates, possibly due to changes in device programming and improvements in heart failure therapies over time.

scholarly journals Mortality and appropriate and inappropriate therapy in patients with ischaemic heart disease and implanted cardioverter-defibrillators for primary prevention: data from the Danish ICD Register

EP Europace ◽  
2013 ◽  
Vol 15 (8) ◽  
pp. 1150-1157 ◽  
Author(s):  
P. Weeke ◽  
J. B. Johansen ◽  
O. D. Jorgensen ◽  
J. C. Nielsen ◽  
M. Moller ◽  
...  
Keyword(s):  
Heart Disease ◽  
Primary Prevention ◽  
Ischaemic Heart Disease ◽  
Inappropriate Therapy ◽  
Cardioverter Defibrillators

Primary Prevention of Cardiovascular Disease

2009 ◽  
Vol 42 (19) ◽  
pp. 37
Author(s):  
WILLIAM E. GOLDEN ◽  
ROBERT H. HOPKINS
Keyword(s):  
Cardiovascular Disease ◽  
Primary Prevention ◽  
Prevention Of Cardiovascular Disease

AAA - a further step towards a moratorium for aspirin in the primary prevention

VASA ◽  
2010 ◽  
Vol 39 (2) ◽  
pp. 119-122
Author(s):  
Minar
Keyword(s):  
Primary Prevention

Primary prevention: Historical perspectives and a blueprint for action.

1986 ◽  
Vol 41 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Stephen E. Goldston
Keyword(s):  
Primary Prevention ◽  
Historical Perspectives

Convention briefs: Primary prevention 'trivialized'

1985 ◽  
Author(s):  
Kathleen Fisher ◽  
Keyword(s):  
Primary Prevention
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