The first cohort of Iranian patients with hyper immunoglobulin E syndrome: A long‐term follow‐up and genetic analysis

Abstract Adoptive transfer of allergen-specific immunoglobulin E (IgE) from atopic donors to nonatopic recipients occurs during the first year following bone marrow transplantation (BMT). Mature B- and T-cell clones with allergen-specific memory and hematopoietic progenitor cells are transferred through BMT. The objective of this study was to characterize the long-term rate of allergic sensitization and development of clinical allergic diseases following BMT from atopic donors. A long-term follow-up study was conducted in a cohort of donor and recipient pairs with moderate-to-severe allergic disease in the donor prior to BMT. Assessments of allergen-specific IgE, clinical rhinitis, and asthma were made in the donors prior to BMT and in the recipients with a mean follow-up of 15.5 years after BMT. From an initial cohort of 12 bone marrow transplant recipients who received marrow from allergic donors, 5 long-term survivors were identified. Allergen-specific IgE transferred from donor to recipient following BMT frequently persisted, and a high rate of de novo allergic sensitization was observed between 1 and 14 years after BMT. These events were associated with elevation in total IgE, and development of allergic rhinitis and asthma at long-term follow-up. We conclude that marrow-derived immune cells from allergic donors can transfer the predisposition to allergy and asthma.

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Long‐term follow‐up of 76 Iranian patients with idiopathic inflammatory myopathies

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.13352 ◽

2018 ◽

Vol 21 (8) ◽

pp. 1627-1633 ◽

Cited By ~ 1

Author(s):

Mehrzad Hajialilo ◽

Amir Ghorbanihaghjo ◽

Alireza Khabbazi ◽

Sousan Kolahi ◽

Mohammad Reza Jafari Nakhjavani ◽

...

Keyword(s):

Idiopathic Inflammatory Myopathies ◽

Inflammatory Myopathies ◽

Long Term Follow Up ◽

Iranian Patients

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Long-term follow-up of ninety eight Iranian patients with primary immune deficiency in a single tertiary centre

Allergologia et Immunopathologia ◽

10.1016/j.aller.2015.09.006 ◽

2016 ◽

Vol 44 (4) ◽

pp. 322-330 ◽

Cited By ~ 10

Author(s):

M. Nabavi ◽

S. Arshi ◽

M.H. Bemanian ◽

A. Aghamohammadi ◽

D. Mansouri ◽

...

Keyword(s):

Immune Deficiency ◽

Primary Immune Deficiency ◽

Tertiary Centre ◽

Long Term Follow Up ◽

Iranian Patients

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Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800105x ◽

2019 ◽

Vol 42 ◽

Cited By ~ 2

Author(s):

John P. A. Ioannidis

Keyword(s):

Mental Health ◽

Mental Disease ◽

Brain Disorders ◽

Social Stressors ◽

Labor Education ◽

Mental Diseases ◽

Long Term Follow Up ◽

Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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