Author response for "Urinary Cyclophilin A and Serum Cystatin C as Biomarkers for Diabetic Nephropathy in Children with Type 1 Diabetes"

Author(s):  
Nanees Abdel‐Badie Salem ◽  
Rania Mostafa El Helaly ◽  
Ibrahim Maroof Ali ◽  
Hala Abd Alem Ebrahim ◽  
Mostafa Mahmoud Alayooti ◽  
...  
2020 ◽  
Vol 21 (5) ◽  
pp. 846-855 ◽  
Author(s):  
Nanees Abdel‐Badie Salem ◽  
Rania Mostafa El Helaly ◽  
Ibrahim Maroof Ali ◽  
Hala Abd Alem Ebrahim ◽  
Mostafa Mahmoud Alayooti ◽  
...  

2011 ◽  
Vol 24 (1) ◽  
pp. 59-63 ◽  
Author(s):  
K. Sahakyan ◽  
B. E. K. Klein ◽  
K. E. Lee ◽  
M. Y. Tsai ◽  
R. Klein

2020 ◽  
Author(s):  
Lina Radzeviciene ◽  
Ingrida Stankute ◽  
Ausra Monstaviciene ◽  
Rimantė Dobrovolskiene ◽  
Evalda Danyte ◽  
...  

Abstract Background. Early capture of initial stages of complications is the destination of long term follow up of type 1 diabetes (T1D) patients. The aim of this study was to assess the clinical significance of serum cystatin C in the early diagnosis of renal injury and its association with dyslipidemia in young T1D patients.Methods. 779 subjects were evaluated for kidney function by estimating glomerular filtration rate (eGFR) based on serum creatinine (eGFRcreat) and cystatin C (eGFRcys). Results. Median age of study subjects was 16.2 years (2.1;26.4), diabetes duration – 5.3 years (0.51;24.0). The median of HbA1c was 8% (5.2;19.9) (64 mmol/mol (33.3;194)); 24.2% of participants had HbA1c <7% (53 mmol/mol). Elevated albumin excretion rate was found in 13.5% of subjects. The median of cystatin C was 0.8 mg/L (0.33;1.71), the median of creatinine – 63 µmol/L (6;126). Median of eGFRcys was lower than eGFRcreat (92 ml/min/1.73m2 vs. 101 ml/min/1.73m2, p<0.001). 30.2% of all patients were classified as having worse kidney function when using cystatin C vs. creatinine for eGFR calculation. Linear correlations were found between cystatin C and HbA1c, r=-0.088, p<0.05, as well as cystatin C and HDL, r=-0.097, p<0.01.Conclusion. This study showed that cystatin C might be used as an additional biomarker of early kidney injury for young patients with T1D.


2020 ◽  
Vol 45 (2) ◽  
Author(s):  
Yiping Cheng ◽  
Chao Xu ◽  
Sichao Wang ◽  
Lin Hou ◽  
Qingbo Guan ◽  
...  

2014 ◽  
Vol 47 (13-14) ◽  
pp. 1235-1238 ◽  
Author(s):  
A. Uruska ◽  
A. Araszkiewicz ◽  
D. Zozulinska-Ziolkiewicz ◽  
M. Wegner ◽  
A. Grzelka ◽  
...  

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