scholarly journals Serum Cystatin C as a Biomarker for Early Diabetic Nephropathy and Dyslipidemia in Young Type 1 Diabetes Patients

2020 ◽  
Author(s):  
Lina Radzeviciene ◽  
Ingrida Stankute ◽  
Ausra Monstaviciene ◽  
Rimantė Dobrovolskiene ◽  
Evalda Danyte ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Function ◽  
Cystatin C ◽  
Young Patients ◽  
Kidney Injury ◽  
Albumin Excretion Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Long Term Follow Up

Abstract Background. Early capture of initial stages of complications is the destination of long term follow up of type 1 diabetes (T1D) patients. The aim of this study was to assess the clinical significance of serum cystatin C in the early diagnosis of renal injury and its association with dyslipidemia in young T1D patients.Methods. 779 subjects were evaluated for kidney function by estimating glomerular filtration rate (eGFR) based on serum creatinine (eGFRcreat) and cystatin C (eGFRcys). Results. Median age of study subjects was 16.2 years (2.1;26.4), diabetes duration – 5.3 years (0.51;24.0). The median of HbA1c was 8% (5.2;19.9) (64 mmol/mol (33.3;194)); 24.2% of participants had HbA1c <7% (53 mmol/mol). Elevated albumin excretion rate was found in 13.5% of subjects. The median of cystatin C was 0.8 mg/L (0.33;1.71), the median of creatinine – 63 µmol/L (6;126). Median of eGFRcys was lower than eGFRcreat (92 ml/min/1.73m2 vs. 101 ml/min/1.73m2, p<0.001). 30.2% of all patients were classified as having worse kidney function when using cystatin C vs. creatinine for eGFR calculation. Linear correlations were found between cystatin C and HbA1c, r=-0.088, p<0.05, as well as cystatin C and HDL, r=-0.097, p<0.01.Conclusion. This study showed that cystatin C might be used as an additional biomarker of early kidney injury for young patients with T1D.

scholarly journals Serum Cystatin C and the Incidence of Hypertension in Type 1 Diabetes Mellitus

2011 ◽  
Vol 24 (1) ◽  
pp. 59-63 ◽  
Author(s):  
K. Sahakyan ◽  
B. E. K. Klein ◽  
K. E. Lee ◽  
M. Y. Tsai ◽  
R. Klein
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

Author response for "Urinary Cyclophilin A and Serum Cystatin C as Biomarkers for Diabetic Nephropathy in Children with Type 1 Diabetes"

2020 ◽  
Author(s):  
Nanees Abdel‐Badie Salem ◽  
Rania Mostafa El Helaly ◽  
Ibrahim Maroof Ali ◽  
Hala Abd Alem Ebrahim ◽  
Mostafa Mahmoud Alayooti ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Cyclophilin A ◽  
Author Response ◽  
Serum Cystatin C ◽  
Serum Cystatin

Urinary Cyclophilin A and serum Cystatin C as biomarkers for diabetic nephropathy in children with type 1 diabetes

2020 ◽  
Vol 21 (5) ◽  
pp. 846-855 ◽  
Author(s):  
Nanees Abdel‐Badie Salem ◽  
Rania Mostafa El Helaly ◽  
Ibrahim Maroof Ali ◽  
Hala Abd Alem Ebrahim ◽  
Mostafa Mahmoud Alayooti ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Cystatin C ◽  
Cyclophilin A ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka

2021 ◽  
Vol 18 (6) ◽  
pp. 3278
Author(s):  
K.S.M. Abdul ◽  
P. Mangala C.S. De Silva ◽  
E.M.D.V. Ekanayake ◽  
W.A.K.G. Thakshila ◽  
S.D. Gunarathna ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Kidney Function ◽  
Cystatin C ◽  
Kidney Injury ◽  
Unknown Etiology ◽  
Urinary Ngal ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Kidney Injury Molecule 1

Extensive use of herbicides is common among rural agricultural workers in Sri Lanka. Recent studies have postulated their role in the development of chronic kidney disease of unknown etiology (CKDu). Paraquat and glyphosate are leading herbicides used by sugarcane farmers (SF), hence occupational exposure is inevitable. This study examined the expression of urinary paraquat, glyphosate and biomarkers among residential SF in CKDu emerging regions, Warunagama (WA) and Rahathangama (RH), in the Uva Province with non-endemic Matara (MA) in the Southern Province of Sri Lanka. Urinary glyphosate, Paraquat, Kidney injury molecule -1 (KIM-I), Neutrophil gelatinase-associated lipocalin (NGAL) andβ2-microglobulin (B2M) were determined using enzyme-linked immunosorbent assays (ELISA). Urinary creatinine, microalbumin, serum creatinine (SCr), serum cystatin C, estimated glomerular filtration rate (eGFR), and albumin creatinine ratio (ACR) were also assessed. Generally, herbicide residues and kidney injury biomarkers were higher in SF compared to the non-endemic MA. Creatinine-adjusted urinary glyphosate and paraquat levels were significantly higher in WA compared to MA. ACR in RH (median 14.9; IQR 5.4–393.1 mg/g) and WA (23.7; 11.5–64.6) was significantly higher than MA (4.3; 2.2–6.7). This study reports 39 individuals with impaired kidney function among SF in Sri Lanka for the first time. Urinary NGAL levels were significantly higher in both WA (median 2.14; IQR 1.28–6.15 ng/mg Cr) and RH (3.09; 1.15–9.09) compared to MA (1.28; 0.56–2.81). However, urinary KIM-I levels in RH (3.2; 1.29–106.1 ng/g Cr) and WA (3.6; 1.94–115.1) were not significantly higher in MA (1.74; 0.76–116.9). Urinary NGAL (r = 0.493), eGFR (r = −0.147) and ACR (r = 0.171) significantly correlated with urinary glyphosate, but not with urinary paraquat levels. Urinary KIM-1 levels did not correlate with either urinary glyphosate or paraquat, while urinary B2M and serum cystatin C levels showed significant correlation with urinary glyphosate levels. The current study reports higher urinary herbicide levels among sugarcane farmers in WA and RH, and that is potentially linked to the subsequent decline in kidney function, as indicated by ACR, eGFR, and NGAL. We posit that these indicators may serve as markers to detect renal injury among herbicide-exposed SF in Rural Sri Lanka.

Does serum cystatin C level reflect insulin resistance in patients with type 1 diabetes?

2014 ◽  
Vol 47 (13-14) ◽  
pp. 1235-1238 ◽  
Author(s):  
A. Uruska ◽  
A. Araszkiewicz ◽  
D. Zozulinska-Ziolkiewicz ◽  
M. Wegner ◽  
A. Grzelka ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Microalbuminuria and Serum Cystatin C Correlation as Early Markers of Kidney Dysfunction in Patients with Type 1 Diabetes Mellitus

2021 ◽  
Author(s):  
K Anuja ◽  
R Kalaivani ◽  
MP Saravanan
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Renal Impairment ◽  
Type 1 Diabetes Mellitus ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Group I ◽  
Type 1 Dm

Introduction: Diabetes mellitus is the most common single cause of End Stage Renal Disease (ESRD). About 20-30% of patients with Type 1 Diabetes Mellitus (Type 1 DM) develop diabetic nephropathy as a serious complication which is the major cause of morbidity and mortality. Early identification of renal impairment is crucial to prevent the progression of nephropathy to a significant degree, because several interventions have greatest impact if initiated very early in the course of the disease. Aim: To study the correlation of microalbuminuria and serum cystatin C for the early prediction of renal impairment in patients with Type 1 DM. Materials and Methods: This was a cross-sectional study conducted from January 2016 to June 2016 on type 1 DM patients attending Diabetology Outpatient Department (OPD). According to the duration of diabetes, pateints were divided into two groups, Group I with <5 years and Group II with >5 years duration. The patients in each group were categorised as cases and controls, based on the Albumin Creatinine Ratio (ACR), serum urea, creatinine, cystatin C, glycated haemoglobin (HbA1c), and urine ACR levels were estimated. Student’s unpaired t-test was used to compare the means between two independent groups. Pearson correlation coefficient was used to estimate the degree of correlation between two quantitative variables. Results: Seventy-two patients with type 1 DM were included in the study. Cystatin C levels in cases (0.89±0.35) when compared to controls (0.67±0.26) in more than five years duration of type 1 DM was found to be statistically significant (p<0.01). Positive correlation between cystatin C and ACR (r=0.4, p<0.05) was found to be statistically significant in more than five years duration. It indicates that serum cystatin C levels increases as the values of ACR increases. There was no significant difference in cystatin C levels in patients with less than five years duration of type 1 DM. Conclusion: Serum cystatin C may be considered as an early predictor of renal impairment in type 1 DM patients with more than five years duration. However, in this study cystatin C carries no significance in less than five years duration of type 1 DM patients.

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