Decision letter for "Extended family history of type 1 diabetes in HLA ‐predisposed children with and without islet autoantibodies"

2020 ◽  
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Extended Family ◽  
Islet Autoantibodies ◽  
History Of

scholarly journals Extended family history of type 1 diabetes in HLA ‐predisposed children with and without islet autoantibodies

2020 ◽  
Vol 21 (8) ◽  
pp. 1447-1456
Author(s):  
Salla Kuusela ◽  
Päivi Keskinen ◽  
Tytti Pokka ◽  
Mikael Knip ◽  
Jorma Ilonen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Extended Family ◽  
Islet Autoantibodies ◽  
History Of

Author response for "Extended family history of type 1 diabetes in HLA ‐predisposed children with and without islet autoantibodies"

2020 ◽  
Author(s):  
Kuusela Salla ◽  
Keskinen Päivi ◽  
Pokka Tytti ◽  
Knip Mikael ◽  
Ilonen Jorma ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Extended Family ◽  
Islet Autoantibodies ◽  
Author Response ◽  
History Of

scholarly journals Extended Family History of Diabetes and Autoimmune Diseases in Children With and Without Type 1 Diabetes

Diabetes Care ◽  
2010 ◽  
Vol 34 (1) ◽  
pp. 115-117 ◽  
Author(s):  
S. Alhonen ◽  
S. Korhonen ◽  
P. Tapanainen ◽  
M. Knip ◽  
R. Veijola
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Autoimmune Diseases ◽  
Extended Family ◽  
Family History Of Diabetes ◽  
History Of

scholarly journals Extended Family History of Type 1 Diabetes and Phenotype and Genotype of Newly Diagnosed Children

Diabetes Care ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 348-354 ◽  
Author(s):  
A. Parkkola ◽  
T. Harkonen ◽  
S. J. Ryhanen ◽  
J. Ilonen ◽  
M. Knip ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Extended Family ◽  
Newly Diagnosed ◽  
History Of

scholarly journals Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes

2013 ◽  
Vol 169 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Anna Parkkola ◽  
Taina Härkönen ◽  
Samppa J Ryhänen ◽  
Jorma Ilonen ◽  
Mikael Knip ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Extended Family ◽  
Positive Family History ◽  
Islet Cell Antibodies ◽  
Metabolic Decompensation ◽  
Newly Diagnosed ◽  
History Of ◽  
Hla Dr3

ObjectiveBased on the concept of clustering autoimmunity, children with a positive family history of autoimmunity could be expected to have a different pathogenetic form of type 1 diabetes (T1D) and thus a stronger autoimmune reactivity against β-cells and an increased prevalence of the HLA-DR3-DQ2 haplotype.Design and methodsWe tested this hypothesis in a cross-sectional observational study from the Finnish Pediatric Diabetes Register. HLA class II genotypes and β-cell autoantibodies were analyzed, and data on the extended family history of autoimmunity and clinical markers at diagnosis were collected with a structured questionnaire from 1488 children diagnosed with T1D under the age of 15 years (57% males).ResultsOnly 23 children (1.5%) had another autoimmune disease (AID) known at diagnosis, and they had a milder metabolic decompensation at diabetes presentation. One-third (31.4%) had at least one relative with an AID other than T1D with affected mothers being overrepresented (8.2%) compared with fathers (2.8%). The children with a positive family history of other AIDs had higher levels of islet cell antibodies (P=0.003), and the HLA-DR3-DQ2 haplotype in the children was associated with celiac disease in the extended family (P<0.001), but not with an increased frequency of autoimmune disorders, in general.ConclusionsApproximately one-third of children with newly diagnosed T1D have a first- and/or second-degree relative affected by an AID. Our data do not consistently support the hypothesis of differential pathogenetic mechanisms in such children.

scholarly journals HHEX-IDE Polymorphism Is Associated with Low Birth Weight in Offspring with a Family History of Type 1 Diabetes

2009 ◽  
Vol 94 (10) ◽  
pp. 4113-4115 ◽  
Author(s):  
Christiane Winkler ◽  
Thomas Illig ◽  
Kerstin Koczwara ◽  
Ezio Bonifacio ◽  
Anette-Gabriele Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Birth Weight ◽  
Family History ◽  
Low Birth Weight ◽  
History Of
Sign in / Sign up

Export Citation Format

Share Document