Light Fluence Rate and Tissue Oxygenation (S t O 2 ) Distributions Within the Thoracic Cavity of Patients Receiving Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma

2020 ◽  
Vol 96 (2) ◽  
pp. 417-425 ◽  
Author(s):  
Pamela J. Dupre ◽  
Yi Hong Ong ◽  
Joseph Friedberg ◽  
Sunil Singhal ◽  
Shirron Carter ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Oxygenation ◽  
Pleural Mesothelioma ◽  
Fluence Rate ◽  
Thoracic Cavity ◽  
Light Fluence

Intracavitary photodynamic therapy for malignant pleural mesothelioma

1995 ◽  
Vol 11 (5) ◽  
pp. 368-371 ◽  
Author(s):  
Hiroshi Takita ◽  
Thomas J. Dougherty
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

Photodynamic Therapy at Low-Light Fluence Rate: in vitro Assays on Colon Cancer Cells

2019 ◽  
Vol 25 (1) ◽  
pp. 1-6 ◽  
Author(s):  
J. A. Rodrigues ◽  
R. Amorim ◽  
M. F. Silva ◽  
F. Baltazar ◽  
R. F. Wolffenbuttel ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluence Rate ◽  
Colon Cancer Cells ◽  
Low Light ◽  
Light Fluence

The Effect of Light Fluence Rate in Photodynamic Therapy of Normal Rat Brain

1992 ◽  
Vol 132 (1) ◽  
pp. 120 ◽  
Author(s):  
Q. Chen ◽  
M. Chopp ◽  
M. O. Dereski ◽  
B. C. Wilson ◽  
M. S. Patterson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Fluence Rate ◽  
Light Fluence ◽  
Normal Rat ◽  
Effect Of Light

Intraoperative Photodynamic Therapy After Pleuropneumonectomy for Malignant Pleural Mesothelioma

CHEST Journal ◽  
2002 ◽  
Vol 122 (5) ◽  
pp. 1866-1867 ◽  
Author(s):  
Pierre Bonnette ◽  
Genevieve Bourg Heckly ◽  
Sandrine Villette ◽  
Alexandra Fragola
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

Intrapleural photodynamic therapy for malignant pleural mesothelioma: A new dosimetry approach

2016 ◽  
Author(s):  
Camille Munck ◽  
Arnaud Scherpereel ◽  
Xavier Dhalluin ◽  
Henri Porte ◽  
Serge Mordon ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

Experimental photodynamic therapy for malignant pleural mesothelioma with pegylatedmTHPC

2003 ◽  
Vol 32 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Thorsten Krueger ◽  
Hans J. Altermatt ◽  
Daniel Mettler ◽  
Beatrix Scholl ◽  
Lennart Magnusson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma
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