Fine‐feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity †

2021 ◽  
Author(s):  
Houston D. Cole ◽  
John A. Roque ◽  
Liubov M. Lifshits ◽  
Rachel Hodges ◽  
Patrick C. Barrett ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes

In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands

2008 ◽  
Vol 14 (29) ◽  
pp. 9046-9057 ◽  
Author(s):  
Isabella Berger ◽  
Muhammad Hanif ◽  
Alexey A. Nazarov ◽  
Christian G. Hartinger ◽  
Roland O. John ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Biologically Relevant

scholarly journals Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds

2009 ◽  
Vol 694 (21) ◽  
pp. 3470-3476 ◽  
Author(s):  
Preshendren Govender ◽  
Nathan C. Antonels ◽  
Johan Mattsson ◽  
Anna K. Renfrew ◽  
Paul J. Dyson ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes

1-(2-Picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity

2011 ◽  
Vol 40 (19) ◽  
pp. 5188 ◽  
Author(s):  
Ioannis Bratsos ◽  
Damijana Urankar ◽  
Ennio Zangrando ◽  
Petia Genova-Kalou ◽  
Janez Košmrlj ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Chelating Ligand

Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1724-1728 ◽  
Author(s):  
Ying Liu ◽  
Yanan Liu ◽  
Licong Yang ◽  
Chengwen Cao ◽  
Yanhui Zhou ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Quadruplex Dna ◽  
G Quadruplex

Thiolato-Bridged Arene-Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2]

2011 ◽  
Vol 2012 (9) ◽  
pp. 1531-1535 ◽  
Author(s):  
Anne-Flore Ibao ◽  
Michaël Gras ◽  
Bruno Therrien ◽  
Georg Süss-Fink ◽  
Olivier Zava ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Dinuclear Complexes

scholarly journals Influence of PPh3 moiety in the anticancer activity of new organometallic ruthenium complexes

2014 ◽  
Vol 136 ◽  
pp. 1-12 ◽  
Author(s):  
Rubén Sáez ◽  
Julia Lorenzo ◽  
Ma Jose Prieto ◽  
Mercè Font-Bardia ◽  
Teresa Calvet ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes

scholarly journals Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity

2010 ◽  
Vol 7 (4) ◽  
pp. 1571-1577 ◽  
Author(s):  
Anjali Jha ◽  
Y. L. N. Murthy ◽  
G. Durga ◽  
T. T. Sundari
Keyword(s):  
Microwave Irradiation ◽  
Metal Complexes ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Conventional Method ◽  
Ruthenium Complexes ◽  
Microwave Assisted Synthesis ◽  
Microwave Irradiation Method ◽  
Anticancer Activities ◽  
Microwave Assisted

Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.

scholarly journals Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

2015 ◽  
Vol 44 (7) ◽  
pp. 3265-3270 ◽  
Author(s):  
A. Rodríguez-Bárzano ◽  
R. M. Lord ◽  
A. M. Basri ◽  
R. M. Phillips ◽  
A. J. Blacker ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Ruthenium Complexes ◽  
Diphosphine Ligands ◽  
Activity Evaluation ◽  
Nanomolar Range

A series of ruthenium complexes with η5-C5(CH3)4R and diphosphine ligands have been synthesised and evaluated in vitro as anticancer agents. IC50 values in the nanomolar range have been obtained against two types of cell lines.

scholarly journals Synthesis, Anticancer Activity, and Genome Profiling of Thiazolo Arene Ruthenium Complexes

2015 ◽  
Vol 58 (21) ◽  
pp. 8475-8490 ◽  
Author(s):  
Adriana Grozav ◽  
Ovidiu Balacescu ◽  
Loredana Balacescu ◽  
Thomas Cheminel ◽  
Ioana Berindan-Neagoe ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes ◽  
Genome Profiling

scholarly journals Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

2009 ◽  
Vol 52 (4) ◽  
pp. 916-925 ◽  
Author(s):  
Maria G. Mendoza-Ferri ◽  
Christian G. Hartinger ◽  
Marco A. Mendoza ◽  
Michael Groessl ◽  
Alexander E. Egger ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Ruthenium Complexes
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