Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma

2016 ◽  
Vol 66 (8) ◽  
pp. 460-465 ◽  
Author(s):  
Tomohiro Enokida ◽  
Satoshi Fujii ◽  
Hirofumi Kuno ◽  
Takashi Mukaigawa ◽  
Makoto Tahara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Pleomorphic Adenoma ◽  
Squamous Cell ◽  
Salivary Duct Carcinoma ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Salivary Duct ◽  
Duct Carcinoma

Parotid Salivary Duct Carcinoma With a Prominent Squamous Component: Immunohistochemical Profile, Diagnostic Pitfalls, and Therapeutic Implications

2021 ◽  
pp. 106689692110019
Author(s):  
Naomi Hardy ◽  
Joshua Thompson ◽  
Ranee Mehra ◽  
Cinthia B. Drachenberg ◽  
Kyle Hatten ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Primary Tumor Site ◽  
Therapeutic Implications ◽  
Variable Morphology ◽  
Diagnostic Pitfalls

Salivary duct carcinoma of the parotid gland is a highly aggressive epithelial malignancy morphologically resembling high-grade, invasive, and in situ breast carcinoma. It can occasionally present with variable morphology making it diagnostically challenging in cases with unusual morphological components. Ancillary testing, particularly androgen receptor (AR) positivity on immunohistochemistry, can be very helpful in cases that demonstrate extensive squamous morphology, since AR positivity is uncommon in both the primary salivary gland and metastatic squamous cell carcinomas to the parotid. In this report, we describe a case of salivary duct carcinoma that showed only a squamous cell carcinoma component on the initial primary tumor site biopsy, as well as in subsequent contralateral neck lymph node and skin metastases. Apart from the variable morphology, the typical salivary duct and squamous cell carcinoma tumor components also showed significant immunohistochemical differences, including differential staining of human epidermal growth factor receptor 2/neu. The associated diagnostic pitfalls, distinct immunoprofiles of the tumor components, helpful adjuncts for making the correct diagnosis, and associated therapeutic implications are discussed.

Immunohistochemical expression of mammaglobin in salivary duct carcinomas de novo and salivary duct carcinoma ex pleomorphic adenoma

2019 ◽  
Vol 92 ◽  
pp. 59-66 ◽  
Author(s):  
Ciro Dantas Soares ◽  
Thayná Melo de Lima Morais ◽  
Roman Carlos ◽  
Manoela Domingues Martins ◽  
Oslei Paes de Almeida ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
De Novo ◽  
Salivary Duct Carcinoma ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Immunohistochemical Expression ◽  
Salivary Duct ◽  
Duct Carcinoma
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