Whole‐genome copy number and immunohistochemical analyses on surgically resected intracholecystic papillary neoplasms

2021 ◽  
Author(s):  
Mia Fujisawa ◽  
Masashi Matushima ◽  
Joaquim Carreras ◽  
Kenji Hirabayashi ◽  
Yara Y. Kikuti ◽  
...  
Keyword(s):  
Copy Number ◽  
Whole Genome ◽  
Genome Copy ◽  
Genome Copy Number ◽  
Immunohistochemical Analyses

scholarly journals Nuclear-cytoplasmic balance: whole genome duplications induce elevated organellar genome copy number

2021 ◽  
Author(s):  
Matheus Fernandes Gyorfy ◽  
Emma R Miller ◽  
Justin L Conover ◽  
Corrinne E Grover ◽  
Jonathan F Wendel ◽  
...  
Keyword(s):  
Copy Number ◽  
Nuclear Genome ◽  
Plant Genome ◽  
Whole Genome ◽  
Genome Copy ◽  
Relative Copy Number ◽  
Organellar Genome ◽  
Plastid Genomes ◽  
Copy Numbers ◽  
Genome Copy Number

The plant genome is partitioned across three distinct subcellular compartments: the nucleus, mitochondria, and plastids. Successful coordination of gene expression among these organellar genomes and the nuclear genome is critical for plant function and fitness. Whole genome duplication events (WGDs) in the nucleus have played a major role in the diversification of land plants and are expected to perturb the relative copy number (stoichiometry) of nuclear, mitochondrial, and plastid genomes. Thus, elucidating the mechanisms whereby plant cells respond to the cytonuclear stoichiometric imbalance that follow WGDs represents an important yet underexplored question in understanding the evolutionary consequences of genome doubling. We used droplet digital PCR (ddPCR) to investigate the relationship between nuclear and organellar genome copy numbers in allopolyploids and their diploid progenitors in both wheat and Arabidopsis. Polyploids exhibit elevated organellar genome copy numbers per cell, largely preserving the cytonuclear stoichiometry observed in diploids despite the change in nuclear genome copy number. To investigate the timescale over which cytonuclear stoichiometry may respond to WGD, we also estimated organellar genome copy number in Arabidopsis synthetic autopolyploids and in a haploid-induced diploid line. We observed corresponding changes in organellar genome copy number in these laboratory-generated lines, indicating that at least some of the cellular response to cytonuclear stoichiometric imbalance is immediate following WGD. We conclude that increases in organellar genome copy numbers represent a common response to polyploidization, suggesting that maintenance of cytonuclear stoichiometry is an important component in establishing polyploid lineages.

The extent of whole-genome copy number alterations predicts aggressive features in primary melanomas

2016 ◽  
Vol 29 (2) ◽  
pp. 163-175 ◽  
Author(s):  
Greta Gandolfi ◽  
Caterina Longo ◽  
Elvira Moscarella ◽  
Iris Zalaudek ◽  
Valentina Sancisi ◽  
...  
Keyword(s):  
Copy Number ◽  
Whole Genome ◽  
Copy Number Alterations ◽  
Genome Copy ◽  
Genome Copy Number

Integrative whole-genome copy number analysis and mutation profiling of FFPE brain tumor specimens and potential in designing multi-arm clinical trials.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 11098-11098
Author(s):  
Shakti Ramkissoon ◽  
Wenya L. Bi ◽  
Sam Haidar ◽  
Jane B. Cryan ◽  
David A. Reardon ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Brain Tumor ◽  
Copy Number ◽  
Whole Genome ◽  
Copy Number Analysis ◽  
Genome Copy ◽  
Genome Copy Number ◽  
Mutation Profiling

scholarly journals Whole-genome copy number variation analysis in anophthalmia and microphthalmia

2013 ◽  
Vol 84 (5) ◽  
pp. 473-481 ◽  
Author(s):  
KF Schilter ◽  
LM Reis ◽  
A Schneider ◽  
TM Bardakjian ◽  
O Abdul-Rahman ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Whole Genome ◽  
Variation Analysis ◽  
Genome Copy ◽  
Copy Number Variation Analysis ◽  
Number Variation ◽  
Genome Copy Number

SU126TARGET SEQUENCING OF GENES INVOLVED IN NEURODEVELOPMENT FROM WHOLE GENOME COPY NUMBER VARIATION ANALYSIS OF JAPANESE SCHIZOPHRENIA

2019 ◽  
Vol 29 ◽  
pp. S1334
Author(s):  
Hiroki Kimura ◽  
Branko Aleksic ◽  
Kanako Ishizuka ◽  
Chenyao Wang ◽  
Itaru Kushima ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Whole Genome ◽  
Variation Analysis ◽  
Genome Copy ◽  
Copy Number Variation Analysis ◽  
Number Variation ◽  
Genome Copy Number

Whole Genome Copy Number Analysis of Formalin Fixed Paraffin Embedded Samples Identifies Major Genomic Aberrations in Medulloblastoma

2014 ◽  
Vol 207 (6) ◽  
pp. 290 ◽  
Author(s):  
Nathan J. Robison ◽  
Ashley S. Margol ◽  
Anju Shukla ◽  
Rebekah J. Kennedy ◽  
Eric Fung ◽  
...  
Keyword(s):  
Copy Number ◽  
Whole Genome ◽  
Copy Number Analysis ◽  
Genome Copy ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Genomic Aberrations ◽  
Genome Copy Number ◽  
Formalin Fixed

Whole-genome copy-number analysis identifies new leads for chromosomal aberrations involved in the oncogenesis and metastastic behavior of uveal melanomas

2015 ◽  
Vol 25 (3) ◽  
pp. 200-209 ◽  
Author(s):  
Adriana C.H. van Engen-van Grunsven ◽  
Marjolein P. Baar ◽  
Rolph Pfundt ◽  
Jos Rijntjes ◽  
Heidi V.N. Küsters-Vandevelde ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Copy Number ◽  
Whole Genome ◽  
Copy Number Analysis ◽  
Genome Copy ◽  
Genome Copy Number ◽  
Uveal Melanomas

Author response for "Whole genome copy number analysis in search of new prognostic biomarkers in first line treatment of mantle cell lymphoma. A study by the LYSA group"

2020 ◽  
Author(s):  
Yannick Le Bris ◽  
Florence Magrangeas ◽  
Anne Moreau ◽  
David Chiron ◽  
Catherine Guérin‐Charbonnel ◽  
...  
Keyword(s):  
Copy Number ◽  
Cell Lymphoma ◽  
Whole Genome ◽  
Line Treatment ◽  
Copy Number Analysis ◽  
Genome Copy ◽  
First Line ◽  
Mantle Cell ◽  
Genome Copy Number ◽  
First Line Treatment
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