c.49T>C mutation on the α-(1,2)-fucosyltransferase gene responsible for an individual with para-Bombay phenotype

Transfusion ◽  
2018 ◽  
Vol 58 (4) ◽  
pp. 1076-1077
Author(s):  
Xiaozhen Hong ◽  
Shu Chen ◽  
Kairong Ma ◽  
Ji He ◽  
Faming Zhu
Keyword(s):  
Fucosyltransferase Gene

Inactivation of the β (1, 2)-xylosyltransferase and the α (1, 3)-fucosyltransferase gene in rice (Oryza sativa) by multiplex CRISPR/Cas9 strategy

2021 ◽  
Author(s):  
Jae-Wan Jung ◽  
Jun-Hye Shin ◽  
Won-Kyung Lee ◽  
Hilal Begum ◽  
Chan-Hong Min ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Fucosyltransferase Gene

Adenovirus-mediated gene transfer of antisense ribozyme for α(1,3)galactosyltransferase gene and α(1,2)fucosyltransferase gene in xenotransplantation

1997 ◽  
Vol 29 (4) ◽  
pp. 2213 ◽  
Author(s):  
S. Hayashi ◽  
T. Nagasaka ◽  
A. Katayama ◽  
I. Saito ◽  
H. Hamada ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Fucosyltransferase Gene

Heterogeneity of the Human H Blood Group alpha (1,2) Fucosyltransferase Gene among Para-Bombay Individuals

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Lung-Chih Yu ◽  
Yun-Hsin Yang ◽  
Richard E. Broadberry ◽  
Yee-Hsiung Chen ◽  
Marie Lin
Keyword(s):  
Blood Group ◽  
Fucosyltransferase Gene

scholarly journals Organization of the Bovine α2-Fucosyltransferase Gene Cluster Suggests that the Sec1 Gene Might Have Been Shaped Through a Nonautonomous L1-Retrotransposition Event Within the Same Locus

2001 ◽  
Vol 18 (11) ◽  
pp. 2083-2091 ◽  
Author(s):  
Katiana Saunier ◽  
Jean-Pierre Barreaud ◽  
André Eggen ◽  
Rafael Oriol ◽  
Hubert Levéziel ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Fucosyltransferase Gene

scholarly journals Correlation of a missense mutation in the human Secretorα1,2-fucosyltransferase gene with the Lewis(a+b+) phenotype: a potential molecular basis for the weak Secretor allele (Sew)

1995 ◽  
Vol 312 (2) ◽  
pp. 329-332 ◽  
Author(s):  
L C Yu ◽  
Y H Yang ◽  
R E Broadberry ◽  
Y H Chen ◽  
Y S Chan ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Molecular Basis ◽  
Double Dose ◽  
Fucosyltransferase Gene ◽  
Lewis A

A missense mutation (A385 to T), predicting an Ile129 to Phe substitution, in the human Secretor alpha 1,2-fucosyltransferase gene was present in double dose in Lewis(a+b+) individuals, but not in Lewis(a-b+) individuals. Co-segregation of the Lewis(a+b+) phenotype with homozygosity for the mutation was also verified. These results yield a potential molecular basis for the weak Secretor allele (Sew) accounting for the Lewis(a+b+) phenotype.

Fucosyltransferase Gene Polymorphisms and Lewisb-Negative Status Are Frequent in Swedish Newborns, With Implications for Infectious Disease Susceptibility and Personalized Medicine

2018 ◽  
Vol 8 (6) ◽  
pp. 507-518 ◽  
Author(s):  
Jovanka R King ◽  
Jezabel Varadé ◽  
Lennart Hammarström
Keyword(s):  
Disease Susceptibility ◽  
Blood Group Antigens ◽  
Nucleotide Polymorphisms ◽  
Nested Polymerase Chain Reaction ◽  
Single Nucleotide ◽  
Fucosyltransferase Gene ◽  
Genotyping Method ◽  
Personalized Health ◽  
Personalized Health Care

Abstract Background Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed in the gut and play an important role in microbial attachment, metabolism, colonization, and shaping of the microbiome. In particular, FUT polymorphisms confer susceptibility to specific rotavirus and norovirus genotypes, which has important global health implications. Methods We designed a genotyping method using a nested polymerase chain reaction approach to determine the frequency of SNPs in FUT2 and FUT3, thereby inferring the prevalence of Lewisb-positive, Lewisb-negative, secretor, and nonsecretor phenotypes in 520 Swedish newborns. Results There was an increased frequency of homozygotes for the minor allele for 1 SNP in FUT2 and 4 SNPs in FUT3. Overall, 37.3% of newborns were found to have Lewis b negative phenotypes (Le (a+b−) or Le (a−b−). Using our new, sensitive genotyping method, we were able to genetically define the Le (a−b−) individuals based on their secretor status and found that the frequency of Lewis b negative newborns in our cohort was 28%. Conclusions Given the high frequency of fucosyltransferase polymorphisms observed in our newborn cohort and the implications for disease susceptibility, FUT genotyping might play a future role in personalized health care, including recommendations for disease screening, therapy, and vaccination.

scholarly journals Heterogeneity of the Human H Blood Group α (1,2) Fucosyltransferase Gene among Para-Bombay Individuals

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Lung-Chih Yu ◽  
Yun-Hsin Yang ◽  
Richard E. Broadberry ◽  
Yee-Hsiung Chen ◽  
Marie Lin
Keyword(s):  
Blood Group ◽  
Fucosyltransferase Gene

scholarly journals Sequence and Expression of a Candidate for the HumanSecretorBlood Group α(1,2)Fucosyltransferase Gene (FUT2)

1995 ◽  
Vol 270 (9) ◽  
pp. 4640-4649 ◽  
Author(s):  
Robert J. Kelly ◽  
Sylvie Rouquier ◽  
Dominique Giorgi ◽  
Gregory G. Lennon ◽  
John B. Lowe
Keyword(s):  
Fucosyltransferase Gene
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