Keep in touch: Nodal connectivity in the control of breathing and blood pressure

2021 ◽  
Author(s):  
Ken D. O'Halloran
Keyword(s):  
Blood Pressure ◽  
Control Of Breathing

scholarly journals Control of breathing and blood pressure by parafacial neurons in conscious rats

2012 ◽  
Vol 98 (1) ◽  
pp. 304-315 ◽  
Author(s):  
Ana C. Takakura ◽  
Thiago S. Moreira ◽  
Patrícia M. De Paula ◽  
José V. Menani ◽  
Eduardo Colombari
Keyword(s):  
Blood Pressure ◽  
Control Of Breathing ◽  
Conscious Rats

scholarly journals Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity

2021 ◽  
Vol 12 ◽  
Author(s):  
Lenise J. Kim ◽  
Mi-Kyung Shin ◽  
Huy Pho ◽  
Laszlo Otvos ◽  
Sergio Tufik ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Leptin Receptor ◽  
Ventilatory Response ◽  
Control Of Breathing ◽  
Receptor Blockade ◽  
Autonomic Balance ◽  
Light Phase ◽  
Control Peptide ◽  
Nzo Mice ◽  
Polygenic Obesity

BackgroundObesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obese individuals with high circulating levels of leptin are resistant to metabolic and respiratory effects of leptin, but they appear to be sensitive to hypertensive effects of this hormone. Obesity-induced hypertension has been associated with hyperleptinemia. New Zealand obese (NZO) mice, a model of polygenic obesity, have high levels of circulating leptin and hypertension, and are prone to develop SDB, similarly to human obesity. We hypothesize that systemic leptin receptor blocker Allo-aca will treat hypertension in NZO mice without any effect on body weight, food intake, or breathing.MethodsMale NZO mice, 12–13 weeks of age, were treated with Allo-aca (n = 6) or a control peptide Gly11 (n = 12) for 8 consecutive days. Doses of 0.2 mg/kg were administered subcutaneously 2×/day, at 10 AM and 6 PM. Blood pressure was measured by telemetry for 48 h before and during peptide infusion. Ventilation was assessed by whole-body barometric plethysmography, control of breathing was examined by assessing the hypoxic ventilatory response (HVR), and polysomnography was performed during light-phase at baseline and during treatment. Heart rate variability analyses were performed to estimate the cardiac autonomic balance.ResultsSystemic leptin receptor blockade with Allo-aca did not affect body weight, body temperature, and food intake in NZO mice. Plasma levels of leptin did not change after the treatment with either Allo-aca or the control peptide Gy11. NZO mice were hypertensive at baseline and leptin receptor blocker Allo-aca significantly reduced the mean arterial pressure from 134.9 ± 3.1 to 124.9 ± 5.7 mmHg during the light phase (P < 0.05), whereas the control peptide had no effect. Leptin receptor blockade did not change the heart rate or cardiac autonomic balance. Allo-aca did not affect minute ventilation under normoxic or hypoxic conditions and HVR. Ventilation, apnea index, and oxygen desaturation during NREM and REM sleep did not change with leptin receptor blockade.ConclusionSystemic leptin receptor blockade attenuates hypertension in NZO mice, but does not exacerbate obesity and SDB. Thus, leptin receptor blockade represents a potential pharmacotherapy for obesity-associated hypertension.

scholarly journals Mutual control of breathing and blood pressure: case report

Spinal Cord ◽  
2007 ◽  
Vol 45 (12) ◽  
pp. 797-798 ◽  
Author(s):  
J H Frisbie
Keyword(s):  
Blood Pressure ◽  
Case Report ◽  
Control Of Breathing

Evaluation of two methods of teaching blood pressure measurement

1988 ◽  
Vol 52 (9) ◽  
pp. 519-521
Author(s):  
NK Nordstrom ◽  
S Longenecker ◽  
HL Whitacre ◽  
FM Beck
Keyword(s):  
Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement

An experimental study in reducing blood pressure in spontaneously hypertensive rats through extracellular signal-regulated kinase inhibition

2010 ◽  
Vol 34 (8) ◽  
pp. S31-S31
Author(s):  
Li Jing ◽  
Jian‑zhong Zhang ◽  
Jin‑ping Sun ◽  
Xin An ◽  
Feng‑ying Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Experimental Study ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Kinase Inhibition ◽  
Spontaneously Hypertensive ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome
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